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CBX4 [nucleoplasm]
Stable Identifier
R-HSA-389118
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA methylation proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates DNMT3A with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates HNRNPK with SUMO2 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
CBX4 SUMOylates BMI1 in PRC1 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
CBX4 SUMOylates CBX4 in PRC1 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
CBX4, UHRF2 SUMOylate ZNF131 with SUMO1 (Homo sapiens)
CBX4, UHRF2 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CASP8AP2 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00257 CBX4
Gene Names
CBX4
Chain
chain:1-560
Reference Genes
BioGPS Gene:8535 CBX4
COSMIC (genes):CBX4 CBX4
CTD Gene:8535 CBX4
dbSNP Gene:8535 CBX4
ENSEMBL:ENSG00000141582 CBX4
ENSEMBL_homo_sapiens_GENE:ENSG00000141582.15 CBX4
HGNC:1554 CBX4
KEGG Gene (Homo sapiens):8535 CBX4
Monarch:8535 CBX4
NCBI Gene:8535 CBX4
OMIM:603079 CBX4
UCSC:O00257 CBX4
Reference Transcript
RefSeq:NM_003655.2 CBX4
Other Identifiers
11727204_a_at
11727205_a_at
16849635
206724_PM_at
206724_at
227558_PM_at
227558_at
31731_at
3773175
3773176
3773177
3773178
3773179
3773180
3773181
3773182
3773183
3773184
3773185
3773186
3773187
3773188
3773190
3773193
3773194
3773195
3773196
3773197
51842_at
8019018
8535
A_23_P89621
GE54123
GO:0000122
GO:0000976
GO:0003677
GO:0003682
GO:0003714
GO:0003723
GO:0003727
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006351
GO:0006355
GO:0012501
GO:0016604
GO:0016607
GO:0016740
GO:0016925
GO:0019789
GO:0019899
GO:0031519
GO:0032183
GO:0035064
GO:0035102
GO:0036211
GO:0042393
GO:0043066
GO:0043226
GO:0045892
GO:0051219
GO:0061665
GO:0140096
GO:0140110
HMNXSV003012434
Hs.5637.0.A1_3p_at
ILMN_1724145
TC17001930.hg
TC17002810.hg
g4502602_3p_at
Participates
as a member of
CBX4, UHRF2 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX8 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
as a component of
monoSUMO1-BMI1:PRC1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K494-CBX4 [nucleoplasm]
Inferred To
Cbx4 [nucleoplasm]
(Mus musculus)
Cbx4 [nucleoplasm]
(Rattus norvegicus)
cbx4 [nucleoplasm]
(Xenopus tropicalis)
CBX4 [nucleoplasm]
(Bos taurus)
CBX4 [nucleoplasm]
(Canis familiaris)
CBX4 [nucleoplasm]
(Gallus gallus)
CBX4 [nucleoplasm]
(Sus scrofa)
zgc:110152 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_003646.2
OpenTargets
ENSG00000141582
ZINC - Substances
CBX4_HUMAN
GeneCards
O00257
HPA
ENSG00000141582-CBX4
ZINC target
O00257
Ensembl
ENST00000269397
,
ENSP00000269397
,
ENSG00000141582
PRO
O00257
Pharos - Targets
O00257
ZINC - Predictions - Purchasable
CBX4_HUMAN
PDB
5EPL
,
2K28
,
3I8Z
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.725
5
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.674
15
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.604
3
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.602
4
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.527
2
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.463
3
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