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EDNRA [plasma membrane]
Stable Identifier
R-HSA-388549
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Endothelin receptor A, RecName: Full=Endothelin-1 receptor; AltName: Full=Endothelin A receptor; Short=hET-AR; Short=ETA-R; Short=ET-A; Flags: Precursor; GN Name=EDNRA; Synonyms=ETA, ETRA; OS Homo sapiens, EDNRA_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:Endothelin [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:Endothelin [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:Endothelin [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:Endothelin [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:Endothelin [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Endothelin receptors bind endothelin (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:Endothelin [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25101 EDNRA
Gene Names
EDNRA, ETA, ETRA
Chain
signal peptide:1-20, chain:21-427
Reference Genes
BioGPS Gene:1909 EDNRA
COSMIC (genes):EDNRA EDNRA
CTD Gene:1909 EDNRA
dbSNP Gene:1909 EDNRA
ENSEMBL:ENSG00000151617 EDNRA
HGNC:3179 EDNRA
KEGG Gene (Homo sapiens):1909 EDNRA
Monarch:1909 EDNRA
NCBI Gene:1909 EDNRA
OMIM:131243 EDNRA
UCSC:P25101 EDNRA
Reference Transcript
RefSeq:NM_001166055.1 EDNRA
RefSeq:NM_001256283.1 EDNRA
RefSeq:NM_001957.3 EDNRA
Other Identifiers
0004590079
11719488_at
11719489_a_at
11747876_a_at
13774
1507_s_at
16971272
18957
1909
204463_s_at
204464_s_at
216235_s_at
2746596
2746597
2746598
2746601
2746602
2746603
2746618
2746623
2746624
2746625
2746627
2746628
2746632
2746633
8097692
A_14_P132706
A_23_P7337
A_24_P217572
A_33_P3401701
AAA58447
AAB20278
AAB20407
AAB23644
AAB25212
AAB25530
AAB36325
AAB36326
AAB36327
AAB94859
AAH22511
AAP32294
AAQ87880
AC093908
AF014826
AK304451
AK312812
AK315931
AY275462
AY422989
BAA01920
BAA14359
BAG35670
BAG65268
BAH14302
BC022511
CAA43953
CAB018957
CCDS3769
CCDS54810
CH471056
D11151
D11151_at
D90348
EAX05019
EAX05021
EDNRA
EDNRA-201
EDNRA-202
EDNRA-204
EDNRA-205
EDNRA-206
EDNRA-208
ENSG00000151617
ENSP00000315011
ENSP00000351359
ENSP00000425281
ENSP00000425354
ENSP00000427259
ENSP00000496976
ENST00000324300
ENST00000324300.10
ENST00000358556
ENST00000358556.8
ENST00000506066
ENST00000506066.1
ENST00000510697
ENST00000510697.5
ENST00000511804
ENST00000511804.5
ENST00000648866
ENST00000648866.1
EntrezGene:1909
EntrezGene:EDNRA
g4503464_3p_a_at
GE59872
GO:0001569
GO:0001666
GO:0001701
GO:0003013
GO:0003674
GO:0004435
GO:0004930
GO:0004962
GO:0005515
GO:0005575
GO:0005623
GO:0005886
GO:0005887
GO:0006810
GO:0006939
GO:0006950
GO:0007165
GO:0007186
GO:0007190
GO:0007193
GO:0007202
GO:0007204
GO:0007507
GO:0007585
GO:0008150
GO:0008217
GO:0008283
GO:0009790
GO:0010827
GO:0014032
GO:0014824
GO:0016020
GO:0016021
GO:0030154
GO:0042310
GO:0042592
GO:0048484
GO:0048646
GO:0048856
GO:0055085
GO:0060322
GO:0086100
HGNC:3179
HPA013774
Hs.76252.0.S2_3p_a_at
Hs.76252.1.S1_3p_a_at
ILMN_1796629
IPR000276
IPR000499
IPR002175
IPR017452
L06622
MIM:131243
MIM:157300
MIM:616367
NM_001166055
NP_001159527
NR_045958
NR_148963
NR_148964
PF00001
PH_hs_0023071
PR00237
PR00366
PR00570
S45956
S55772
S57498
S63938
S67127
S81539
S81542
S81545
TC04000729.hg
TC04002255.hg
UPI00000503F9
UPI000006D809
UPI0000071AB8
UPI0001D3B8DF
X61950
Participant Of
hasMember
EDNRA,EDNRB [plasma membrane]
Inferred To
EDNRA [plasma membrane] (Bos taurus)
EDNRA [plasma membrane] (Danio rerio)
EDNRA [plasma membrane] (Gallus gallus)
EDNRA [plasma membrane] (Mus musculus)
EDNRA [plasma membrane] (Rattus norvegicus)
EDNRA [plasma membrane] (Xenopus tropicalis)
Cross References
ZINC - Investigational
EDNRA_HUMAN
RefSeq
NP_001243212.1
,
NP_001948.1
,
NP_001159527.1
ZINC - World Drugs
EDNRA_HUMAN
OpenTargets
ENSG00000151617
ZINC - FDA approved
EDNRA_HUMAN
ZINC - Substances
EDNRA_HUMAN
GeneCards
P25101
ZINC target
P25101
PRO
P25101
Orphanet
23587
ZINC - Predictions - Purchasable
EDNRA_HUMAN
HMDB Protein
HMDBP02261
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49407 ARRB1
5
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [cytosol]
(R-HSA-264470)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
3
UniProt:P32121 ARRB2
2
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [cytosol]
(R-HSA-416464)
0.499
2
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