PAPP-A2 proteolyzes IGF:IGFBP5:ALS

Stable Identifier
R-HSA-381537
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Both Pregnancy Associated Plasma Protein A (PAPP-A) and A2 (PAPP-A2) cleave IGFBP-5 in the IGF:IGFBP-5:ALS Complex between amino acids 163 and 164, releasing IGF. PPAP-A has also been shown to cleave IGFBP-5 that is not complexed with IGF.

Literature References
PubMed ID Title Journal Year
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
11522292 Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A

Laursen, LS, Overgaard, MT, Søe, R, Boldt, HB, Sottrup-Jensen, L, Giudice, LC, Conover, CA, Oxvig, C

FEBS Lett 2001
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
11788658 Molecular distribution of IGF binding protein-5 in human serum

Baxter, RC, Meka, S, Firth, SM

J Clin Endocrinol Metab 2002
11264294 Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase

Overgaard, MT, Boldt, HB, Laursen, LS, Sottrup-Jensen, L, Conover, CA, Oxvig, C

J Biol Chem 2001
11606061 Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells

Schneider, MR, Zhou, R, Hoeflich, A, Krebs, O, Schmidt, J, Mohan, S, Wolf, E, Lahm, H

Biochem Biophys Res Commun 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of PAPPA,PAPPA2 [extracellular region]
Physical Entity
Activity
Orthologous Events
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Created
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