IGFBP6 binds IGF forming IGF:IGFBP6

Stable Identifier
R-HSA-381503
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IGFBP-6 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP-6. IGFBP-6 binds IGF II with greater affinity than IGF I.

Literature References
PubMed ID Title Journal Year
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM

J Biol Chem 1993
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
15525596 Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding

Headey, SJ, Leeding, KS, Norton, RS, Bach, LA

J Mol Endocrinol 2004
15308688 C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II

Headey, SJ, Keizer, DW, Yao, S, Brasier, G, Kantharidis, P, Bach, LA, Norton, RS

Mol Endocrinol 2004
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM

Experientia 1993
8781553 Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography

Bach, LA, Rechler, MM

Biochim Biophys Acta 1996
7525263 Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts

Bach, LA, Hsieh, S, Brown, AL, Rechler, MM

Endocrinology 1994
10951195 O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis

Marinaro, JA, Neumann, GM, Russo, VC, Leeding, KS, Bach, LA

Eur J Biochem 2000
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