Plasmin proteolyzes IGF:IGFBP-3:ALS

Stable Identifier
R-HSA-381461
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Plasmin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 124 and 125 and between amino acids 187 and 188, releasing IGF.

Literature References
PubMed ID Title Journal Year
7588299 Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3)

Angelloz-Nicoud, P, Binoux, M

Endocrinology 1995
7527330 Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells

Lalou, C, Silve, C, Rosato, R, Segovia, B, Binoux, M

Endocrinology 1994
8964575 Isolation and characterization of proteolytic fragments of insulin-like growth factor-binding protein-3

Lalou, C, Lassarre, C, Binoux, M

Horm Res 1996
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
10990447 Prostate carcinoma (PC-3) cell proliferation is stimulated by the 22-25-kDa proteolytic fragment (1-160) and inhibited by the 16-kDa fragment (1-95) of recombinant human insulin-like growth factor binding protein-3

Angelloz-Nicoud, P, Lalou, C, Binoux, M

Growth Horm IGF Res 1998
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
8894645 Recombinant human insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases

Angelloz-Nicoud, P, Harel, L, Binoux, M

Growth Regul 1996
8817670 Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth

Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P

Prog Growth Factor Res 1995
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
11739083 IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis

Booth, BA, Boes, M, Dake, BL, Knudtson, KL, Bar, RS

Am J Physiol Endocrinol Metab 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Plasmin [extracellular region]
Physical Entity
Activity
Orthologous Events
Reviewed
Created