Thrombin proteolyzes IGF:IGFBP3:ALS

Stable Identifier
R-HSA-381446
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Thrombin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 124 and 125 and between amino acids 233 and 234, releasing IGF.

Literature References
PubMed ID Title Journal Year
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
8817670 Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth

Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P

Prog Growth Factor Res 1995
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
11739083 IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis

Booth, BA, Boes, M, Dake, BL, Knudtson, KL, Bar, RS

Am J Physiol Endocrinol Metab 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
Physical Entity
Activity
Orthologous Events
Reviewed
Created