Reactome | EP300 [nucleoplasm]

EP300 [nucleoplasm]

Stable Identifier

R-HSA-381325

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p300, Histone acetyltransferase p300, EP300_HUMAN, KAT3B

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Locations in the PathwayBrowser for interactor UniProt:Q13309 SKP2

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External Reference Information

External Reference

UniProt:Q09472 EP300

Gene Names

EP300, P300

Chain

initiator methionine:1, chain:2-2414

Reference Genes

BioGPS Gene:2033 EP300

COSMIC (genes):EP300 EP300

CTD Gene:2033 EP300

dbSNP Gene:2033 EP300

ENSEMBL:ENSG00000100393 EP300

HGNC:3373 EP300

KEGG Gene (Homo sapiens):2033 EP300

Monarch:2033 EP300

NCBI Gene:2033 EP300

OMIM:602700 EP300

UCSC:Q09472 EP300

Reference Transcript

RefSeq:NM_001429.3 EP300

Other Identifiers

0001770148

11725127_at

146

16930534

17119320

1L3E

1P4Q

202221_s_at

2033

213579_s_at

2K8F

2MH0

2MZD

3128

33896_at

3946616

3946617

3946618

3946619

3946627

3946629

3946631

3946632

3946634

3946637

3946638

3946640

3946641

3946642

3946643

3946645

3946646

3946649

3946651

3946652

3946653

3946655

3946656

3946657

3946658

3946660

3946665

3946667

3946669

3946671

3946672

3946673

3946674

3946675

3946676

3946677

3946678

3946679

3946682

3946683

3946684

3946685

3946686

3946687

3946688

3946689

3946690

3946691

3BIY

3I3J

3IO2

3P57

3T92

4112

4BHW

4PZR

4PZS

4PZT

551_at

5BT3

5KJ2

5LKT

5LKU

5LKX

5LKZ

5LPK

5LPM

5NU5

5XZC

5XZS

6DS6

6FGN

6FGS

6GYR

6GYT

8073345

A0A0U1RQG3

A_14_P108084

A_14_P127141

A_23_P40693

A_24_P7887

AAA18639

AL035658

AL080243

AL096765

CAB000146

CCDS14010

CH471095

EAW60408

ENSG00000100393

ENSP00000263253

ENST00000263253

ENST00000263253.8

EntrezGene:2033

EntrezGene:EP300

EP300

EP300-201

GE58850

GO:0000122

GO:0000123

GO:0000278

GO:0000902

GO:0000977

GO:0000978

GO:0001085

GO:0001102

GO:0001666

GO:0001756

GO:0001966

GO:0002039

GO:0002209

GO:0002223

GO:0002376

GO:0003674

GO:0003677

GO:0003682

GO:0003684

GO:0003712

GO:0003713

GO:0003723

GO:0004402

GO:0004468

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0005975

GO:0006259

GO:0006283

GO:0006355

GO:0006357

GO:0006464

GO:0006473

GO:0006475

GO:0006914

GO:0006915

GO:0006950

GO:0006977

GO:0006990

GO:0007049

GO:0007165

GO:0007219

GO:0007221

GO:0007399

GO:0007507

GO:0007519

GO:0007611

GO:0007623

GO:0008013

GO:0008022

GO:0008092

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0009056

GO:0009058

GO:0009790

GO:0009887

GO:0010506

GO:0010628

GO:0010742

GO:0010976

GO:0016032

GO:0016407

GO:0016573

GO:0016579

GO:0016740

GO:0016746

GO:0018076

GO:0018393

GO:0018394

GO:0022607

GO:0030154

GO:0030183

GO:0030220

GO:0030324

GO:0030511

GO:0031333

GO:0031490

GO:0031648

GO:0032092

GO:0032481

GO:0032991

GO:0032993

GO:0033613

GO:0034641

GO:0034644

GO:0035257

GO:0035264

GO:0035855

GO:0036268

GO:0040007

GO:0040011

GO:0042771

GO:0043167

GO:0043226

GO:0043627

GO:0043923

GO:0043967

GO:0043969

GO:0044281

GO:0044403

GO:0045444

GO:0045652

GO:0045721

GO:0045747

GO:0045815

GO:0045893

GO:0045944

GO:0046872

GO:0048156

GO:0048511

GO:0048646

GO:0048856

GO:0050681

GO:0050821

GO:0050877

GO:0051059

GO:0051091

GO:0051276

GO:0051604

GO:0051726

GO:0060325

GO:0060765

GO:0061418

GO:0061733

GO:0061920

GO:0061921

GO:0065003

GO:0090043

GO:0097157

GO:0097677

GO:0140065

GO:0140066

GO:0140067

GO:0140068

GO:0140069

GO:1900034

GO:1901224

GO:1901796

GO:1904837

GO:1905636

HGNC:3373

HPA003128

HPA004112

Hs.25272.0.A2_3p_a_at

Hs.25272.1.A1_3p_a_at

ILMN_1744665

ILMN_3309419

IPR000197

IPR000433

IPR001487

IPR003101

IPR009110

IPR010303

IPR013083

IPR013178

IPR014744

IPR018359

IPR031162

IPR035898

IPR036427

IPR036529

IPR037073

IPR038547

MIM:114500

MIM:180849

MIM:602700

MIM:613684

MIM:618333

NM_001362843

NM_001429

NP_001349772

NP_001420

PF00439

PF00569

PF02135

PF02172

PF06001

PF08214

PF09030

PH_hs_0023353

PH_hs_0032399

PR00503

SM00291

SM00297

SM00551

SM01250

TC22000332.hg

U01877

U01877_at

UPI00001AE876

Participant Of

hasComponent

input

output

hasMember

hasCandidate

KAT2B,(EP300) [nucleoplasm]

This entity regulates

Negatively

SMURFs ubiquitinate RUNX3

Other forms of this molecule

SUMO1-K1020,1024-EP300 [nucleoplasm]

Foxo4-S-S-EP300 [nucleoplasm]

FOXO4-S-S-EP300 [nucleoplasm]

p-S,T-EP300 [nucleoplasm]

Inferred To

Ghost homologue of EP300 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of EP300 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of EP300 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of EP300 [nucleoplasm] (Schizosaccharomyces pombe)

EP300 [nucleoplasm] (Bos taurus)

EP300 [nucleoplasm] (Caenorhabditis elegans)

EP300 [nucleoplasm] (Canis familiaris)

EP300 [nucleoplasm] (Danio rerio)

EP300 [nucleoplasm] (Drosophila melanogaster)

EP300 [nucleoplasm] (Gallus gallus)

EP300 [nucleoplasm] (Mus musculus)

EP300 [nucleoplasm] (Rattus norvegicus)

EP300 [nucleoplasm] (Sus scrofa)

EP300 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001420.2

OpenTargets

ENSG00000100393

ZINC - Substances

EP300_HUMAN

ZINC - Biogenic

EP300_HUMAN

ZINC target

Q09472

PRO

Q09472

PDB

5KJ2, 5LKZ, 6GYT, 5XZC, 1P4Q, 2MH0, 1L3E, 5NU5, 4PZR, 6FGS, 6GYR, 5LKX, 3IO2, 6DS6, 4BHW, 5LPM, 3BIY, 5BT3, 6FGN, 3T92, 5LPK, 5LKU, 4PZT, 3P57, 3I3J, 5LKT, 6K4N, 2MZD, 4PZS, 2K8F

ZINC - Metabolites

EP300_HUMAN

IntEnz

2.3.1.48

GeneCards

Q09472

Orphanet

15982

ZINC - Predictions - Purchasable

EP300_HUMAN

HMDB Protein

HMDBP00011

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.974	21
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.962	20
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.734	4
UniProt:P27695 APEX1	1	APEX1 [nucleoplasm] (R-HSA-50119)	0.724	8
UniProt:P24941 CDK2	5	CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.723	6
UniProt:P03255 E1A			0.702	3
UniProt:P03255-2			0.702	3
UniProt:Q9QXM1	2	JMY [nucleoplasm] (R-MMU-6804234) PolyUb-JMY [nucleoplasm] (R-MMU-6804247)	0.66	16
UniProt:Q04206 RELA	6	MeK310-RELA [nucleoplasm] (R-HSA-8865233) SUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642)	0.658	4
UniProt:P06790 VE2			0.658	6
UniProt:O15350 TP73	3	TP73 [cytosol] (R-HSA-8957239) PolyUb-TP73 [cytosol] (R-HSA-8957256) TP73 [nucleoplasm] (R-HSA-6798094)	0.653	3
UniProt:P03259 E1A			0.646	3
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.623	5
UniProt:P17844 DDX5	3	SUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) DDX5 [nucleoplasm] (R-HSA-3900136) SUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.61	4
UniProt:Q9H2X6 HIPK2	3	p-HIPK2 [nucleoplasm] (R-HSA-6799375) SUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405) HIPK2 [nucleoplasm] (R-HSA-3215222)	0.602	4
UniProt:P03126 VE6			0.602	8
UniProt:P20265 PO3F2			0.602	3
UniProt:O60934 NBN	3	NBN [nucleoplasm] (R-HSA-75163) NBN [cytosol] (R-HSA-5684005) p-S343-NBN [nucleoplasm] (R-HSA-75237)	0.602	5
UniProt:P03129 VE7			0.593	14
UniProt:Q9NPI1 BRD7	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.591	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.591	4
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.589	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.589	2
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.576	3
UniProt:Q01844 EWS			0.573	2
UniProt:P61201 COPS2	2	COPS2 [nucleoplasm] (R-HSA-5697012) COPS2 [cytosol] (R-HSA-416971)	0.558	2
UniProt:Q13761 RUNX3	7	p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.558	7
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.553	2
UniProt:P11473 VDR	2	VDR [nucleoplasm] (R-HSA-375512) SUMO2-VDR [nucleoplasm] (R-HSA-4546376)	0.547	3
UniProt:P55209 NP1L1			0.544	3
UniProt:Q08369	1	GATA4 [nucleoplasm] (R-MMU-400553)	0.544	2
UniProt:P06422 VE2			0.544	7
IntAct:EBI-1550784 CDKN1A			0.527	3
IntAct:EBI-1776214 KLK3			0.527	2
UniProt:O95863 SNAI1	1	SNAI1 [nucleoplasm] (R-HSA-2980903)	0.525	3
UniProt:K4P3M7 K4P3M7			0.524	4
UniProt:Q13309 SKP2	2	SKP2 [nucleoplasm] (R-HSA-975554) SKP2 [cytosol] (R-HSA-975495)	0.524	3
UniProt:P56279 TCL1A			0.524	4
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.524	2
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.508	7
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.508	3
UniProt:Q61221	7	2xHP-HIF1A [nucleoplasm] (R-MMU-1234105) HN-HIF1A [cytosol] (R-MMU-1234110) 2xHP-HIF1A [cytosol] (R-MMU-1234131) phospho-p-Y565,S797-HIF1A [cytosol] (R-MMU-9634700) phospho-p-Y565-HIF1A [cytosol] (R-MMU-8857584) HIF1A [cytosol] (R-MMU-1234102) HIF1A [nucleoplasm] (R-MMU-1234135)	0.499	2
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.499	2
UniProt:Q8WXX7 AUTS2	1	AUTS2 [nucleoplasm] (R-HSA-8937967)	0.499	3
UniProt:Q9UL17 TBX21			0.499	5
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.499	2
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.499	2
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.488	2
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.462	2
UniProt:Q12905 ILF2	4	ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995)	0.462	2
UniProt:P06930 VE6			0.462	2
UniProt:P06428 VE6			0.462	2