Reactome | Dissociation of PERK:BiP Heterodimer

Dissociation of PERK:BiP Heterodimer

Stable Identifier

R-HSA-381086

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

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PERK (EIF2AK3) is a single-pass transmembrane protein located in the Endoplasmic Reticulum (ER) membrane. PERK has an N-terminal luminal domain and a C-terminal cytosolic domain. It is maintained in an inactive state by association of its luminal domain with BiP, a chaperone in the ER. Because BiP also binds unfolded proteins, BiP dissociates from PERK when unfolded proteins exceed chaperone activity in the ER.

Literature References

PubMed ID	Title	Journal	Year
11907036	Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress Ma, K, Vattem, KM, Wek, RC	J Biol Chem	2002
17956313	PERK in the life and death of the pancreatic beta-cell Herbert, TP	Biochem Soc Trans	2007

Participants

Input

Output

Participant Of

hasEvent

PERK regulates gene expression

Authored

May, B (2009-06-02)

Reviewed

D'Eustachio, P (2008-12-02)

Matthews, L (2008-12-02)

Gillespie, ME (2008-12-02)

Urano, F (2010-04-30)

Created

May, B (2008-11-19)