Reactome | ATF4 [nucleoplasm]

ATF4 [nucleoplasm]

Stable Identifier

R-HSA-381016

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q9Y297 BTRC

Expand all

External Reference Information

External Reference

UniProt:P18848 ATF4

Gene Names

ATF4, CREB2, TXREB

Chain

chain:1-351

Reference Genes

BioGPS Gene:468 ATF4

COSMIC (genes):ATF4 ATF4

CTD Gene:468 ATF4

dbSNP Gene:468 ATF4

ENSEMBL:ENSG00000128272 ATF4

HGNC:786 ATF4

KEGG Gene (Homo sapiens):468 ATF4

Monarch:468 ATF4

NCBI Gene:468 ATF4

OMIM:604064 ATF4

UCSC:P18848 ATF4

Reference Transcript

Other Identifiers

0001340494

0006660022

11596

11757047_x_at

16930299

1CI6

200779_at

3349635

3349636

3349639

3349641

3349642

3349644

3771453

3771455

3771457

3771459

3945913

3945915

3945916

3945917

3945918

3945919

3945920

3945921

3945922

3945923

3945924

3945925

3945926

3945927

3945928

3945930

3945931

3945932

3945933

3996611

3996613

3996627

4027513

4027529

4027531

41235_at

468

8073148

8180337

A_23_P120933

A_23_P120941

AAA52071

AAH08090

AAH11994

AAH16855

AAH22088

AAH24775

AAH44895

AAH73754

AAH73990

AL022312

ATF4

ATF4-201

ATF4-202

ATF4-203

BAA14234

BC008090

BC011994

BC016855

BC022088

BC024775

BC044895

BC073754

BC073990

CAB011596

CAG30270

CCDS13996

CH471095

CR456384

D90209

D90209_at

EAW60341

EAW60342

ENSG00000128272

ENSP00000336790

ENSP00000379912

ENSP00000384587

ENST00000337304

ENST00000337304.2

ENST00000396680

ENST00000396680.2

ENST00000404241

ENST00000404241.6

EntrezGene:468

EntrezGene:ATF4

g4502264_3p_at

GE81054

GO:0000228

GO:0000790

GO:0000977

GO:0000978

GO:0000980

GO:0000981

GO:0001085

GO:0001228

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0005886

GO:0005975

GO:0006094

GO:0006355

GO:0006357

GO:0006366

GO:0006412

GO:0006810

GO:0006874

GO:0006950

GO:0007165

GO:0007214

GO:0007623

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0009058

GO:0009636

GO:0010575

GO:0010628

GO:0016020

GO:0019899

GO:0019901

GO:0030154

GO:0030182

GO:0032057

GO:0032590

GO:0032922

GO:0032991

GO:0034198

GO:0034399

GO:0034641

GO:0034644

GO:0034976

GO:0036003

GO:0036091

GO:0036499

GO:0042149

GO:0042592

GO:0042789

GO:0043005

GO:0043065

GO:0043226

GO:0043267

GO:0043522

GO:0043525

GO:0043565

GO:0044212

GO:0044281

GO:0045893

GO:0045943

GO:0045944

GO:0046982

GO:0048511

GO:0048856

GO:0061395

GO:0070059

GO:0070169

GO:0090575

GO:0090650

GO:0120163

GO:1903204

GO:1903351

GO:1905461

GO:1990037

GO:1990440

GO:1990589

GO:1990590

GO:1990617

GO:1990737

GO:2000120

HGNC:786

ILMN_1672128

ILMN_1688964

ILMN_1783394

ILMN_2358457

IPR004827

IPR029811

M86842

MIM:604064

NM_001675

NM_182810

NP_001666

NP_877962

PF00170

PH_hs_0027945

SM00338

TC22000317.hg

UPI000000DABF

XM_017028807

XP_016884296

Participant Of

input

hasComponent

output

Translation of ATF4

This entity regulates

Positively

Cross References

RefSeq

XP_016884296.1, NP_001666.2, NP_877962.1

OpenTargets

ENSG00000128272

GeneCards

P18848

PRO

P18848

PDB

1CI6

HMDB Protein

HMDBP08114

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.921	19
UniProt:Q96RU7 TRIB3	3	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.86	14
UniProt:Q13515 BFSP2			0.841	9
UniProt:Q9BWC9 CC106			0.817	12
UniProt:P53567 CEBPG	1	CEBPG [nucleoplasm] (R-HSA-9644320)	0.774	10
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.764	9
UniProt:O14777 NDC80	1	NDC80 [cytosol] (R-HSA-375314)	0.764	6
UniProt:O95751 LDOC1			0.742	9
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.733	7
UniProt:Q9NS37 ZHANG			0.704	6
UniProt:Q0D2H9 GOG8D			0.696	5
UniProt:Q92805 GOLGA1	1	GOLGA1 [cytosol] (R-HSA-6813882)	0.696	8
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.696	5
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.633	6
UniProt:P01100 FOS	2	p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283) FOS [nucleoplasm] (R-HSA-450216)	0.609	3
IntAct:EBI-21404505 APOE			0.602	3
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.592	3
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.573	2
UniProt:Q08AF8 GOG8F			0.556	6
UniProt:P33297	4	PSMC3 [extracellular region] (R-SCE-6806496) PSMC3 [secretory granule lumen] (R-SCE-6800917) PSMC3 [ficolin-1-rich granule lumen] (R-SCE-6800429) PSMC3 [cytosol] (R-SCE-68774)	0.556	3
UniProt:A0A0S2Z507 A0A0S2Z507			0.556	6
UniProt:B7Z3H4 B7Z3H4			0.556	3
UniProt:Q9NRI5 DISC1			0.553	4
UniProt:Q99871 HAUS7	1	HAUS7 [cytosol] (R-HSA-8855200)	0.553	3
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.553	2
UniProt:O95721 SNAP29	3	SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997) SNAP29 [azurophil granule membrane] (R-HSA-6799359)	0.553	2
UniProt:Q9Y297-2 BTRC			0.543	5
UniProt:Q16236 NF2L2			0.499	4
UniProt:Q96NT1 NP1L5			0.488	2
UniProt:Q9Y592-2 CEP83			0.488	2
UniProt:A2RTX5 SYTC2			0.488	2
UniProt:Q86UD0 SAPC2			0.488	2
UniProt:Q9BXS5 AP1M1	7	AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.488	2
UniProt:Q08AF8-2 GOLGA8F			0.488	2
UniProt:Q8WYK2 JDP2			0.488	2