Reactome | STAT binds to the active receptor

STAT binds to the active receptor

Stable Identifier

R-HSA-380782

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Among the seven members of the STAT family, STAT1, STAT3, STAT5 alpha and -beta, and STAT6 have been shown to bind to the activated PDGF beta-receptor (PDGFRB) and to be phosphorylated after PDGF stimulation; binding also occurs to the alpha-receptor (PDGFRA), albeit only weakly.

Literature References

PubMed ID	Title	Journal	Year
9739761	Signal transduction via platelet-derived growth factor receptors Ostman, A, Heldin, CH, Rönnstrand, L	Biochim Biophys Acta	1998
8657151	Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins Gilman, M, Watling, D, Rogers, NC, Sadowski, HB, Vignais, ML	Mol Cell Biol	1996
9484840	Activation of Stat5 by platelet-derived growth factor (PDGF) is dependent on phosphorylation sites in PDGF beta-receptor juxtamembrane and kinase insert domains Paukku, K, Valgeirsdóttir, S, Silvennoinen, O, Heldin, CH, Claesson-Welsh, L	Oncogene	1998