Reactome | CEP63 [cytosol]

CEP63 [cytosol]

Stable Identifier

R-HSA-380267

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep63

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP63 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96MT8 CEP63

Gene Names

CEP63

Chain

chain:1-703

Reference Genes

BioGPS Gene:80254 CEP63

COSMIC (genes):CEP63 CEP63

CTD Gene:80254 CEP63

dbSNP Gene:80254 CEP63

ENSEMBL:ENSG00000182923 CEP63

ENSEMBL_homo_sapiens_GENE:ENSG00000182923.20 CEP63

HGNC:25815 CEP63

KEGG Gene (Homo sapiens):80254 CEP63

Monarch:80254 CEP63

NCBI Gene:80254 CEP63

OMIM:614724 CEP63

UCSC:Q96MT8 CEP63

Reference Transcript

Other Identifiers

11724856_a_at

11724857_s_at

11724858_a_at

11735022_at

11740958_x_at

16945933

219242_PM_at

219242_at

222151_3p_s_at

222151_PM_s_at

222151_s_at

2643533

2643534

2643535

2643536

2643537

2643538

2643543

2643546

2643547

2643548

2643550

2643551

2643559

2643560

2643561

2643562

2643563

2643564

2643565

2643570

2643571

2643573

2643574

2643575

2643577

2643578

2643579

2643580

2643581

2643582

2643583

2643584

2643585

50502_at

63355_at

69014_at

70115_at

80254

8082827

A_14_P100520

A_14_P104378

A_14_P113177

A_14_P134076

A_32_P32585

GE83117

GE845708

GO:0000077

GO:0000922

GO:0002376

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0006974

GO:0007010

GO:0007049

GO:0007059

GO:0007099

GO:0023052

GO:0030154

GO:0034451

GO:0036211

GO:0042770

GO:0043226

GO:0045824

GO:0048856

GO:0050821

GO:0051225

GO:0051301

GO:0060090

GO:0098535

GO:0098542

GO:1900045

HMNXSV003014935

HMNXSV003041299

Hs.300876.1.S1_3p_a_at

Hs.300876.1.S1_3p_at

Hs.300876.1.S1_3p_x_at

ILMN_1787808

ILMN_2288297

ILMN_2294294

ILMN_2396011

PH_hs_0021221

PH_hs_0037237

TC03000729.hg

g13376771_3p_at

Participates

as a component of

Inferred To

Cep63 [cytosol] (Mus musculus)

Cep63 [cytosol] (Rattus norvegicus)

cep63 [cytosol] (Xenopus tropicalis)

CEP63 [cytosol] (Bos taurus)

CEP63 [cytosol] (Canis familiaris)

CEP63 [cytosol] (Gallus gallus)

CEP63 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001035842.1, XP_016862756.1, XP_016862743.1, XP_016862744.1, XP_016862751.1, NP_001035843.1, XP_005247854.1, XP_016862745.1, XP_016862752.1, XP_011511496.1, XP_016862753.1, NP_001035859.1, NP_079456.2, XP_016862755.1, XP_006713823.1

OpenTargets

ENSG00000182923

GeneCards

Q96MT8

HPA

ENSG00000182923-CEP63

Ensembl

ENST00000683608, ENSP00000507217, ENST00000354446, ENSP00000507704, ENST00000513612, ENSP00000426129, ENST00000383229, ENSP00000506728, ENSP00000506828, ENST00000606977, ENSP00000346432, ENST00000682858, ENST00000682800, ENST00000682042, ENSP00000475903, ENST00000683596, ENST00000332047, ENST00000683177, ENSP00000506791, ENST00000512894, ENSG00000182923, ENST00000620544, ENSP00000423225, ENST00000684677, ENSP00000508291, ENST00000683861, ENSP00000482219, ENST00000684217, ENSP00000507703, ENSP00000506896, ENSP00000507228, ENSP00000372716, ENSP00000502085, ENST00000675561, ENSP00000328382

PRO

Q96MT8

Pharos - Targets

Q96MT8

Orphanet

20805

PDB

7W91, 6CSV, 6CSU

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.739	5
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [cytosol] (R-HSA-265276) ALOX5 [secretory granule lumen] (R-HSA-6801306) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) ALOX5 [cytosol] (R-HSA-429010) p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765)	0.666	4
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.666	4
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.659	4
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.659	4
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.564	2
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:Q13813 SPTAN1	6	SPTAN1 [cytosol] (R-HSA-201601) SPTAN1(1-1185) [cytosol] (R-HSA-202944) SPTAN1(1186-2472) [cytosol] (R-HSA-202964) SPTAN1 [specific granule lumen] (R-HSA-6799533) SPTAN1 [extracellular region] (R-HSA-6806322) SPTAN1 [tertiary granule lumen] (R-HSA-6800874)	0.547	2
UniProt:Q2M1P5 KIF7	1	KIF7 [ciliary tip] (R-HSA-5610395)	0.483	4

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