Reactome | DARS2 [mitochondrial matrix]

DARS2 [mitochondrial matrix]

Stable Identifier

R-HSA-379679

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Aspartyl-tRNA synthetase 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q6PI48 DARS2

Gene Names

DARS2

Chain

transit peptide:1-47, chain:48-645

Reference Genes

BioGPS Gene:55157 DARS2

COSMIC (genes):DARS2 DARS2

CTD Gene:55157 DARS2

dbSNP Gene:55157 DARS2

ENSEMBL:ENSG00000117593 DARS2

ENSEMBL_homo_sapiens_GENE:ENSG00000117593.12 DARS2

HGNC:25538 DARS2

KEGG Gene (Homo sapiens):55157 DARS2

Monarch:55157 DARS2

NCBI Gene:55157 DARS2

OMIM:610956 DARS2

UCSC:Q6PI48 DARS2

Reference Transcript

RefSeq:NM_018122.4 DARS2

Other Identifiers

11726602_at

11726603_at

16673983

218365_PM_s_at

218365_s_at

2367844

2367845

2367846

2367852

2367854

2367856

2367857

2367858

2367859

2367860

2367861

2367862

2367863

2367864

2367866

2367870

2367873

2367874

2367875

2367876

2367877

2367878

2367879

55157

64470_at

7907466

86801_at

A_23_P148984

GE55771

GO:0000049

GO:0000166

GO:0003676

GO:0003723

GO:0003824

GO:0004812

GO:0004815

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0006399

GO:0006412

GO:0006418

GO:0006422

GO:0006520

GO:0016874

GO:0031966

GO:0042803

GO:0043039

GO:0043226

GO:0050560

GO:0070145

GO:0140053

GO:0140098

HMNXSV003005910

Hs.59346.0.S1_3p_a_at

ILMN_1676191

PH_hs_0003811

TC01001516.hg

Participates

as a component of

DARS2 dimer [mitochondrial matrix] (Homo sapiens)

Cross References

RefSeq

NP_060592.2

OpenTargets

ENSG00000117593

HPA

ENSG00000117593-DARS2

GeneCards

Q6PI48

Ensembl

ENSP00000497569, ENSG00000117593, ENST00000649689

PRO

Q6PI48

Pharos - Targets

Q6PI48

Orphanet

17187

PDB

4AH6

HMDB Protein

HMDBP09252

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.65	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	5
UniProt:Q8NFJ9 BBS1	1	BBS1 [cytosol] (R-HSA-5617640)	0.508	2

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