Reactome | CGA [extracellular region]

CGA [extracellular region]

Stable Identifier

R-HSA-378967

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Glycoprotein hormones alpha chain, GLHA_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01215 CGA

Gene Names

CGA

Chain

signal peptide:1-24, chain:25-116

Reference Genes

BioGPS Gene:1081 CGA

COSMIC (genes):CGA CGA

CTD Gene:1081 CGA

dbSNP Gene:1081 CGA

ENSEMBL:ENSG00000135346 CGA

ENSEMBL_homo_sapiens_GENE:ENSG00000135346.9 CGA

HGNC:1885 CGA

KEGG Gene (Homo sapiens):1081 CGA

Monarch:1081 CGA

NCBI Gene:1081 CGA

OMIM:118850 CGA

UCSC:P01215 CGA

Reference Transcript

Other Identifiers

1081

11743032_at

17021437

204637_PM_at

204637_at

2963623

2963624

2963626

2963628

2963634

39352_at

8128001

A_23_P42386

A_24_P371782

GE60521

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005794

GO:0005796

GO:0006351

GO:0006355

GO:0006575

GO:0006590

GO:0006629

GO:0007165

GO:0007186

GO:0008284

GO:0008406

GO:0009755

GO:0010469

GO:0010893

GO:0016913

GO:0016914

GO:0022414

GO:0023052

GO:0030335

GO:0030878

GO:0032275

GO:0032870

GO:0035265

GO:0042699

GO:0043226

GO:0045944

GO:0046621

GO:0046884

GO:0048018

GO:0048589

GO:0048856

GO:0048870

GO:0050886

GO:0061696

GO:0098772

HMNXSV003048946

ILMN_1734176

PH_hs_0006603

PH_hs_0035545

S70585_rna1_at

TC06001926.hg

g10800407_3p_at

Participates

as an input of

as an output of

TFAP2A,TFAP2C homodimers stimulate CGA gene expression (Homo sapiens)

as a component of

Other forms of this molecule

S-glyco-CGA [Golgi lumen]

CGA [Golgi lumen]

Inferred To

GPA1 [extracellular region] (Canis familiaris)

cga [extracellular region] (Xenopus tropicalis)

Cga [extracellular region] (Mus musculus)

Cga [extracellular region] (Rattus norvegicus)

CGA [extracellular region] (Bos taurus)

CGA [extracellular region] (Gallus gallus)

CGA [extracellular region] (Sus scrofa)

GPHa [extracellular region] (Danio rerio)

Modified Residues

Name

glycosylated residue (N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 76

Coordinate

Modification

N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group

PsiMod Name

glycosylated residue

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.

Name

glycosylated residue (N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group) at 102

Coordinate

102

Modification

N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl group

PsiMod Name

glycosylated residue

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.

Cross References

RefSeq

NP_001239312.1, NP_000726.1

OpenTargets

ENSG00000135346

HPA

ENSG00000135346-CGA

GeneCards

P01215

Ensembl

ENSP00000486024, ENST00000627148, ENSG00000135346

PRO

P01215

Pharos - Targets

P01215

Orphanet

24407

PDB

1HRP, 4MQW, 7FII, 1HD4, 7FIH, 4AY9, 7UTZ, 1XWD, 1FL7, 7FIG, 1E9J, 1DZ7, 7T9I, 7XW5, 1QFW, 8I2G, 1HCN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01225 FSHB	1	FSHB [extracellular region] (R-HSA-378993)	0.756	4
UniProt:P0DN86 CGB3	1	CGB3 [extracellular region] (R-HSA-8936343)	0.592	2

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