CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1

Stable Identifier
R-HSA-3788708
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cyclin A-Cdk2 (CCNA:CDK2) prevents unscheduled APC reactivation during S phase by binding and subsequently phosphorylating FZR1 (Cdh1). Phosphorylation-dependent dissociation of the Cdh1-activating subunit inhibits the APC/C (Sorensen et al. 2001). DNA damage activates ATM kinase, resulting in TP53-mediated induction of CDKN1A (p21) expression. CDKN1A binds CCNA:CDK2 complex and prevents its association with Cdh1 (Takahashi et al. 2012).
Literature References
PubMed ID Title Journal Year
11340163 A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression

Lukas, J, Peters, JM, Kramer, ER, Sorensen, CS, Lukas, C

Mol Cell Biol 2001
22178396 DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells

Peters, G, Yoshimoto, S, Shinkai, Y, Imai, Y, Tachibana, M, Takahashi, A, Saya, H, Takeuchi, T, Hori, S, Hara, E, Kuninaka, S, Yamakoshi, K, Ohtani, N, Anderton, E

Mol. Cell 2012
Participants
Participates
This event is regulated
Orthologous Events
Authored
Reviewed
Created
Cite Us!