Reactome | SLC7A1 [plasma membrane]

SLC7A1 [plasma membrane]

Stable Identifier

R-HSA-375771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

CAT-1, High affinity cationic amino acid transporter 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30825 SLC7A1

Gene Names

SLC7A1, ATRC1, ERR, REC1L

Chain

chain:1-629

Reference Genes

BioGPS Gene:6541 SLC7A1

COSMIC (genes):SLC7A1 SLC7A1

CTD Gene:6541 SLC7A1

dbSNP Gene:6541 SLC7A1

ENSEMBL:ENSG00000139514 SLC7A1

HGNC:11057 SLC7A1

KEGG Gene (Homo sapiens):6541 SLC7A1

Monarch:6541 SLC7A1

NCBI Gene:6541 SLC7A1

OMIM:104615 SLC7A1

UCSC:P30825 SLC7A1

Reference Transcript

Other Identifiers

0002100138

11722411_a_at

11722412_s_at

11722413_a_at

11722414_at

16777777

206566_at

212290_at

212292_at

212295_s_at

237858_s_at

3507709

3507711

3507712

3507713

3507714

3507715

3507720

3507723

3507724

3507728

3507729

3507731

3507733

3507734

3507736

3507737

3507740

3507743

3507746

3507757

36274_at

39721

39748_at

49611_at

6541

7970810

A0A024RDQ9

A_24_P253251

AAC27721

AAH63303

AAH69358

AAI15408

AF078107

AL596114

BC063303

BC069358

BC115407

CAA40560

CAA41869

CCDS9333

CH471075

EAX08443

EAX08444

ENSG00000139514

ENSP00000370128

ENST00000380752

ENST00000380752.9

EntrezGene:6541

EntrezGene:SLC7A1

g4507046_3p_at

GE59825

GO:0000064

GO:0003674

GO:0005515

GO:0005575

GO:0005623

GO:0005886

GO:0005887

GO:0006810

GO:0006865

GO:0008150

GO:0015171

GO:0015181

GO:0015189

GO:0015809

GO:0016020

GO:0016021

GO:0022857

GO:0032991

GO:0055085

GO:0097638

GO:1903352

GO:1903401

GO:1903826

HGNC:11057

HPA039721

Hs.14846.0.A1_3p_at

Hs.14846.0.A2_3p_at

Hs.14846.0.A3_3p_a_at

Hs.22287.0.A1_3p_at

ILMN_1683859

IPR002293

IPR004755

IPR029485

MIM:104615

NM_003045

NP_003036

PF13520

PF13906

PH_hs_0031019

Q5JR49

SLC7A1

SLC7A1-201

TC13000523.hg

UPI0000128653

X57303

X57303_at

X59155

XM_005266507

XM_017020713

XP_005266564

XP_016876202

Inferred To

Homologues of SLC7A1 [plasma membrane] (Dictyostelium discoideum)

SLC7A1 [plasma membrane] (Bos taurus)

SLC7A1 [plasma membrane] (Canis familiaris)

SLC7A1 [plasma membrane] (Danio rerio)

SLC7A1 [plasma membrane] (Dictyostelium discoideum)

SLC7A1 [plasma membrane] (Drosophila melanogaster)

SLC7A1 [plasma membrane] (Gallus gallus)

SLC7A1 [plasma membrane] (Mus musculus)

SLC7A1 [plasma membrane] (Rattus norvegicus)

SLC7A1 [plasma membrane] (Sus scrofa)

SLC7A1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_005266564.1, NP_003036.1, XP_016876205.1

OpenTargets

ENSG00000139514

GeneCards

P30825

PRO

P30825

Orphanet

24921

HMDB Protein

HMDBP03222

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q969F0 FATE1			0.696	5
UniProt:Q9BSR8 YIPF4			0.621	3
UniProt:Q9NUM3 S39A9			0.488	2
UniProt:P13236 CCL4	1	CCL4(24-92) [extracellular region] (R-HSA-443976)	0.488	2
UniProt:Q8N3T1 GALNT15	1	GALNT15 [Golgi membrane] (R-HSA-913705)	0.488	2
IntAct:EBI-12181075 FCER1G			0.488	2
UniProt:O00258 WRB	1	WRB [endoplasmic reticulum membrane] (R-HSA-9609521)	0.488	2
UniProt:P11912 CD79A	2	CD79A [plasma membrane] (R-HSA-197154) p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539)	0.488	2
UniProt:Q9BV81 EMC6			0.488	2
UniProt:Q9NRQ5 SMCO4			0.488	2
UniProt:Q9Y6G1 TM14A			0.488	2
UniProt:O15243 OBRG			0.488	2
UniProt:Q9GZY8-5 MFF			0.488	2
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) APOA2(24-100) [early endosome] (R-HSA-2569092) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.488	2
UniProt:Q8TDT2 GP152			0.488	4
UniProt:P54315 PNLIPRP1	1	PNLIPRP1 [extracellular region] (R-HSA-3902876)	0.488	2
UniProt:P47884 OR1D4	1	OR1D4 [plasma membrane] (R-HSA-378651)	0.488	2
IntAct:EBI-17206288 NUCB2			0.488	2
UniProt:Q9NWF4 SLC52A1	1	SLC52A1 [plasma membrane] (R-HSA-5216118)	0.488	2
UniProt:O14735 CDIPT	1	CDIPT [endoplasmic reticulum membrane] (R-HSA-1498749)	0.488	2
UniProt:Q8N138 ORMDL3	4	ORMDL3 [secretory granule membrane] (R-HSA-6800882) ORMDL3 [endoplasmic reticulum membrane] (R-HSA-8865589) ORMDL3 [plasma membrane] (R-HSA-6806293) ORMDL3 [specific granule membrane] (R-HSA-6799643)	0.488	2
UniProt:A5PKU2 A5PKU2			0.488	2
UniProt:P50876 RNF144A	1	RNF144A [endosome membrane] (R-HSA-8938771)	0.488	2
UniProt:Q15436 SEC23A	4	SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) p-S742,T747 SEC23A [cytosol] (R-HSA-5685740)	0.488	2
UniProt:P27352 CBLIF	4	GIF [extracellular region] (R-HSA-2980918) GIF S27Cfs*23 [extracellular region] (R-HSA-3315461) GIF [endosome] (R-HSA-3000150) GIF [lysosomal lumen] (R-HSA-3000272)	0.488	2
UniProt:O60242 AGRB3			0.488	2
UniProt:Q9BSE4 HERP2			0.488	2
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.488	2
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.488	2
UniProt:P43378 PTPN9	1	PTPN9 [nucleoplasm] (R-HSA-9008907)	0.488	2
UniProt:P21964 COMT	2	COMT [plasma membrane] (R-HSA-379386) COMT [cytosol] (R-HSA-175974)	0.488	2
UniProt:P25942 CD40			0.488	2
UniProt:P27449 ATP6V0C	7	ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [endosome membrane] (R-HSA-912591)	0.488	2
UniProt:Q96Q45-2 TMEM237			0.488	2
UniProt:Q05940 SLC18A2	2	SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372544) SLC18A2 [plasma membrane] (R-HSA-374907)	0.488	2
UniProt:Q9HA82 CERS4	1	CERS4 [endoplasmic reticulum membrane] (R-HSA-428138)	0.488	2
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.488	2
UniProt:Q96JF0-2 ST6GAL2			0.488	2
UniProt:P16278 GLB1	8	GLB1 [ficolin-1-rich granule lumen] (R-HSA-6800968) GLB1 [lysosomal lumen] (R-HSA-1605623) GLB1 [extracellular region] (R-HSA-6806213) GLB1 [azurophil granule lumen] (R-HSA-6799124) GLB1 W273L [lysosomal lumen] (R-HSA-2262738) GLB1 R482C [lysosomal lumen] (R-HSA-2262739) GLB1 Y83C [lysosomal lumen] (R-HSA-2262735) GLB1 W509C [lysosomal lumen] (R-HSA-2262732)	0.488	2
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.488	2
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.488	2
UniProt:Q96BA8 CREB3L1	7	CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.488	2
UniProt:P55061 BI1			0.488	2
UniProt:Q8TAZ6 CKLF2			0.488	2