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INCENP [cytosol]
Stable Identifier
R-HSA-375311
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
INCENP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NQS7 INCENP
Gene Names
INCENP
Chain
chain:1-918
Reference Genes
BioGPS Gene:3619 INCENP
COSMIC (genes):INCENP INCENP
CTD Gene:3619 INCENP
dbSNP Gene:3619 INCENP
ENSEMBL:ENSG00000149503 INCENP
ENSEMBL_homo_sapiens_GENE:ENSG00000149503.13 INCENP
HGNC:6058 INCENP
KEGG Gene (Homo sapiens):3619 INCENP
Monarch:3619 INCENP
NCBI Gene:3619 INCENP
OMIM:604411 INCENP
UCSC:Q9NQS7 INCENP
Reference Transcript
RefSeq:NM_001040694.1 INCENP
RefSeq:NM_020238.2 INCENP
Other Identifiers
11733188_at
11733189_at
16725806
219769_PM_at
219769_at
242787_PM_at
242787_at
3194908
3333357
3333361
3333362
3333363
3333364
3333365
3333366
3333371
3333372
3333373
3333376
3333377
3333378
3333381
3333382
3333383
3333384
3333385
3333386
3333387
3333389
3333390
3333391
3333392
3333393
3333394
3333395
3333400
3619
59013_r_at
60489_r_at
76984_at
7940600
88327_at
A_23_P116387
GE541098
GO:0000228
GO:0000278
GO:0000281
GO:0000775
GO:0000776
GO:0000795
GO:0000800
GO:0000801
GO:0000910
GO:0001934
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005721
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0007010
GO:0007049
GO:0007052
GO:0007059
GO:0010369
GO:0015630
GO:0016604
GO:0022414
GO:0023052
GO:0030496
GO:0032133
GO:0032991
GO:0036211
GO:0043226
GO:0043232
GO:0051256
GO:0051257
GO:0051301
GO:0051310
GO:0090267
GO:0098772
GO:0140013
GO:0140014
GO:0140677
GO:1901970
GO:1902425
GO:1903490
GO:1990385
HMNXSV003012558
Hs.142179.0.A1_3p_at
ILMN_2355738
PH_hs_0022566
TC11000546.hg
g9910375_3p_at
Participates
as a component of
SUMO2,3:Chromosome passenger complex [cytosol] (Homo sapiens)
Chromosome passenger complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
Other forms of this molecule
INCENP [nucleoplasm]
Inferred To
INCENP [cytosol]
(Bos taurus)
INCENP [cytosol]
(Canis familiaris)
INCENP [cytosol]
(Gallus gallus)
INCENP [cytosol]
(Sus scrofa)
incenp [cytosol]
(Xenopus tropicalis)
Incenp [cytosol]
(Drosophila melanogaster)
Incenp [cytosol]
(Mus musculus)
Incenp [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001035784.1
,
NP_064623.2
OpenTargets
ENSG00000149503
HPA
ENSG00000149503-INCENP
GeneCards
Q9NQS7
Ensembl
ENSG00000149503
,
ENST00000394818
,
ENSP00000278849
,
ENST00000278849
,
ENSP00000378295
PRO
Q9NQS7
Pharos - Targets
Q9NQS7
PDB
6GR9
,
4AF3
,
6YIH
,
6YIF
,
6GR8
,
5IEK
,
5IEH
,
2QFA
,
6YIE
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96GD4 AURKB
3
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [nucleoplasm]
(R-HSA-4655360)
AURKB [cytosol]
(R-HSA-174231)
0.953
19
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.888
10
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.798
11
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.499
2
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