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SPC25 [cytosol]
Stable Identifier
R-HSA-375307
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
hSpc25
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
KMN network [cytosol] (Homo sapiens)
NDC80 complex [cytosol] (Homo sapiens)
SPC25 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HBM1 SPC25
Gene Names
SPC25, SPBC25, AD024
Chain
chain:1-224
Reference Genes
BioGPS Gene:57405 SPC25
COSMIC (genes):SPC25 SPC25
CTD Gene:57405 SPC25
dbSNP Gene:57405 SPC25
ENSEMBL:ENSG00000152253 SPC25
ENSEMBL_homo_sapiens_GENE:ENSG00000152253.9 SPC25
ENSEMBL_homo_sapiens_GENE:ENSG00000277909.4 SPC25
HGNC:24031 SPC25
KEGG Gene (Homo sapiens):57405 SPC25
Monarch:57405 SPC25
NCBI Gene:57405 SPC25
OMIM:609395 SPC25
UCSC:Q9HBM1 SPC25
Reference Transcript
RefSeq:NM_020675.3 SPC25
Other Identifiers
11723998_at
16904780
209891_PM_at
209891_at
2585934
2585935
2585937
2585939
2585941
2585943
2585944
2585948
38940_at
57405
8056572
A_23_P51085
GE82558
GO:0000278
GO:0000775
GO:0000776
GO:0005515
GO:0005634
GO:0005694
GO:0005829
GO:0007010
GO:0007049
GO:0007052
GO:0007059
GO:0007094
GO:0008608
GO:0023052
GO:0031262
GO:0043226
GO:0051301
GO:0140014
HMNXSV003053090
ILMN_1814281
ILMN_2149400
PH_hs_0019754
TC02002507.hg
g9963834_3p_at
Participates
as a component of
NDC80 complex [cytosol] (Homo sapiens)
Inferred To
SPC25 [cytosol]
(Bos taurus)
SPC25 [cytosol]
(Canis familiaris)
SPC25 [cytosol]
(Gallus gallus)
SPC25 [cytosol]
(Sus scrofa)
Spc25 [cytosol]
(Mus musculus)
Spc25 [cytosol]
(Rattus norvegicus)
spc25 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_065726.1
OpenTargets
ENSG00000152253
GeneCards
Q9HBM1
HPA
ENSG00000152253-SPC25
Ensembl
ENSP00000282074
,
ENST00000611144
,
ENSP00000481354
,
ENSP00000483050
,
ENSG00000277909
,
ENST00000616584
,
ENSG00000152253
,
ENST00000282074
PRO
Q9HBM1
Pharos - Targets
Q9HBM1
PDB
3IZ0
,
2VE7
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
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