DCC interaction with Netrin-1

Stable Identifier
R-HSA-373711
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Netrin-1 promotes attraction of the commissural neurons to midline cells. It is secreted in the ventral midline (also known as the floor plate). The transmembrane DCC receptor is a Netrin-1 receptor, involved in the attractive effects of Netrin-1. Contact-dependent mechanisms promote extension of growth cones across the floor plate to the contralateral side, whereupon growth cones acquire sensitivity to the midline repellent Slit and grow away from the midline.
Netrin-1 binds directly to the fifth Fibronectin III motif of DCC, thereby inducing DCC clustering through the association between the DCC P3 domains, a process required for an attractive response.

Literature References
PubMed ID Title Journal Year
9950216 Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas

Meyerhardt, JA, Caca, K, Eckstrand, BC, Hu, G, Lengauer, C, Banavali, S, Look, AT, Fearon, ER

Cell Growth Differ 1999
11239160 Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation

Stein, E, Zou, Y, Poo, M, Tessier-Lavigne, M

Science 2001
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