Reactome | ACHE [extracellular region]

ACHE [extracellular region]

Stable Identifier

R-HSA-372506

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Acetylcholinesterase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22303 ACHE

Gene Names

ACHE

Chain

signal peptide:1-31, chain:32-614

Reference Genes

BioGPS Gene:43 ACHE

COSMIC (genes):ACHE ACHE

CTD Gene:43 ACHE

dbSNP Gene:43 ACHE

ENSEMBL:ENSG00000087085 ACHE

ENSEMBL_homo_sapiens_GENE:ENSG00000087085.16 ACHE

HGNC:108 ACHE

KEGG Gene (Homo sapiens):43 ACHE

Monarch:43 ACHE

NCBI Gene:43 ACHE

OMIM:100740 ACHE

UCSC:P22303 ACHE

Reference Transcript

Other Identifiers

11733279_a_at

11733280_a_at

17060791

205377_PM_s_at

205377_s_at

205378_PM_s_at

205378_s_at

3064357

3064358

3064359

3064360

3064362

3064363

3064364

3064365

3064366

3064367

3064369

3064370

3064371

3064372

3064374

3064375

3064376

3064377

3064378

3064379

3064380

40249_at

8141643

8141648

ADDON002502.hg

A_24_P60845

GE82034

GO:0001507

GO:0001540

GO:0001919

GO:0002076

GO:0003824

GO:0003990

GO:0004104

GO:0005515

GO:0005518

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0005794

GO:0005886

GO:0006581

GO:0007155

GO:0007399

GO:0007416

GO:0009986

GO:0016020

GO:0016192

GO:0016787

GO:0017171

GO:0023052

GO:0030154

GO:0030312

GO:0031012

GO:0031594

GO:0031623

GO:0032223

GO:0034330

GO:0042166

GO:0042802

GO:0042803

GO:0042982

GO:0043083

GO:0043226

GO:0043236

GO:0043621

GO:0045202

GO:0048471

GO:0048856

GO:0050714

GO:0052689

GO:0060041

GO:0095500

GO:0098552

GO:0120162

HMNXSV003013565

HMNXSV003053971

Hs.154495.0.S1_3p_a_at

Hs.157779.0.A1_3p_at

ILMN_1780485

ILMN_2333219

M55040_at

PH_hs_0009299

S71129_at

TC07001679.hg

TC07001680.hg

g7710111_3p_a_at

Participates

as a candidate of

Butyrylcholinesterase [extracellular region] (Homo sapiens)

Other forms of this molecule

ACHE [plasma membrane]

Inferred To

ACHE [extracellular region] (Gallus gallus)

Cross References

RefSeq

XP_006716058.1, NP_000656.1, NP_056646.1, XP_011514530.1, NP_001289550.1, NP_001269378.1, NP_001289551.1, XP_011514531.1

ZINC - World Drugs

ACES_HUMAN

Guide to Pharmacology - Targets

2465

OpenTargets

ENSG00000087085

ZINC - FDA approved

ACES_HUMAN

ZINC - Substances

ACES_HUMAN

ZINC target

P22303

ZINC - Biogenic

ACES_HUMAN

PRO

P22303

PDB

8DT7, 7E3H, 4BDT, 6NEA, 6CQV, 4EY5, 6WVQ, 6O69, 6CQU, 6NTN, 7RB7, 7XN1, 6WVP, 6O66, 4EY4, 6WUZ, 4PQE, 5HF9, 6CQZ, 5HQ3, 4EY7, 7D9P, 5FOQ, 8DT5, 5HF5, 6ZWE, 6NTL, 1B41, 5HF6, 7D9O, 8AEN, 4M0E, 6NTO, 6O5R, 6O4X, 6O50, 1F8U, 5HFA, 6CQW, 6NTH, 4EY8, 6U37, 6O4W, 3LII, 1VZJ, 6WV1, 7E3D, 6U34, 7D9Q, 6NTG, 2X8B, 6CQT, 7RB6, 8DT4, 6NTM, 6WVO, 6F25, 4M0F, 8AEV, 6CQY, 6O5V, 8DT2, 7RB5, 5HF8, 6WUY, 6U3P, 6O52, 5FPQ, 6NTK, 4EY6, 6CQX, 6WVC, 6WUV, 6O5S

ZINC - Investigational

ACES_HUMAN

ZINC - Metabolites

ACES_HUMAN

GeneCards

P22303

HPA

ENSG00000087085-ACHE

Ensembl

ENSP00000241069, ENSP00000414858, ENST00000302913, ENST00000428317, ENST00000419336, ENSP00000394976, ENSP00000303211, ENSG00000087085, ENST00000412389, ENST00000241069, ENST00000411582, ENSP00000403474, ENSP00000404865

Pharos - Targets

P22303

ZINC - Predictions - Purchasable

ACES_HUMAN

HMDB Protein

HMDBP00524

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y215 COLQ			0.558	2
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.527	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.527	2