Apoptotic cleavage of cell adhesion proteins

Stable Identifier
R-HSA-351906
Type
Pathway
Species
Homo sapiens
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Apoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al., 2000). Desmosome-specific members of the cadherin superfamily of cell adhesion molecules including desmoglein-3, plakophilin-1 and desmoplakin are cleaved by caspases after onset of apoptosis (Weiske et al., 2001). Cleavage results in the disruption of the desmosome structure and thus contributes to cell rounding and disintegration of the intermediate filament system (Weiske et al., 2001).

Literature References
PubMed ID Title Journal Year
17559062 The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery

Cirillo, N, Lanza, M, De Rosa, A, Cammarota, M, La Gatta, A, Gombos, F, Lanza, A

J Cell Biochem 2008
11500511 The fate of desmosomal proteins in apoptotic cells

Weiske, J, Schoneberg, T, Schroder, W, Hatzfeld, M, Tauber, R, Huber, O

J Biol Chem 2001
16286477 The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes

Dusek, RL, Getsios, S, Chen, F, Park, JK, Amargo, EV, Cryns, VL, Green, KJ

J Biol Chem 2006
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