Caspase-mediated cleavage of vimentin at TNLD (429)

Stable Identifier
R-HSA-350318
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Vimentin is cleaved by several caspases during apoptosis (Morishima et al., 1999, Byun et al., 2001). This clevage disrupts the cytoplasmic network of intermediate filaments and coincides temporally with nuclear fragmentation. Caspase-6 recognizes and cleaves C terminal side of Asp-429.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-6 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created