Reactome | MTA1 [nucleoplasm]

MTA1 [nucleoplasm]

Stable Identifier

R-HSA-3465550

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Metastasis-associated protein MTA1, MTA1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13330 MTA1

Gene Names

MTA1

Chain

chain:1-715

Reference Genes

BioGPS Gene:9112 MTA1

COSMIC (genes):MTA1 MTA1

CTD Gene:9112 MTA1

dbSNP Gene:9112 MTA1

ENSEMBL:ENSG00000182979 MTA1

HGNC:7410 MTA1

KEGG Gene (Homo sapiens):9112 MTA1

Monarch:9112 MTA1

NCBI Gene:9112 MTA1

OMIM:603526 MTA1

UCSC:Q13330 MTA1

Reference Transcript

Other Identifiers

0004120204

11727668_a_at

11746358_a_at

11757774_x_at

1642_at

1643_g_at

16789681

202247_s_at

211783_s_at

3554748

3554749

3554760

3554767

3554776

3554778

3554780

3554781

3554785

3554787

3554788

3554790

3554792

3554794

3554795

3554796

3554797

3554799

3554800

3554802

3554805

3554806

3554810

3554812

3554813

3554815

3554816

3554817

38633_at

4508

4BKX

4PBY

4PBZ

4PC0

5544

5FXY

5ICN

6G16

7977373

9112

A_14_P123899

A_23_P9513

A_24_P241370

A_24_P241373

A_33_P3359306

AAA78935

AAH09443

AAI42942

AAN01613

AF508978

AL928654

BC009443

BC142941

BX248776

CAB004508

CAD66583

CCDS32169

CCDS55954

E7ESY4

ENSG00000182979

ENSP00000333633

ENSP00000384180

ENSP00000393438

ENST00000331320

ENST00000331320.11

ENST00000405646

ENST00000405646.5

ENST00000438610

ENST00000438610.5

EntrezGene:9112

EntrezGene:MTA1

F8W9Y9

g13544097_3p_s_at

GE59104

GO:0000122

GO:0000228

GO:0000978

GO:0000980

GO:0001103

GO:0003674

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0006259

GO:0006302

GO:0006355

GO:0006464

GO:0006950

GO:0007165

GO:0008134

GO:0008150

GO:0008270

GO:0009056

GO:0009058

GO:0010212

GO:0016575

GO:0016581

GO:0019899

GO:0032922

GO:0032991

GO:0034641

GO:0040029

GO:0042826

GO:0043153

GO:0043161

GO:0043167

GO:0043226

GO:0043231

GO:0043565

GO:0045475

GO:0046872

GO:0048511

GO:0051276

GO:1902499

GO:1903508

H0Y4T7

HGNC:7410

HPA005544

Hs.101448.0.S1_3p_s_at

ILMN_1671911

IPR000679

IPR000949

IPR001005

IPR001025

IPR009057

IPR017884

IPR035170

IPR040138

MIM:603526

MTA1

MTA1-201

MTA1-202

MTA1-208

NM_001203258

NM_004689

NP_001190187

NP_004680

PF00249

PF00320

PF01426

PF01448

PF17226

PH_hs_0005642

SM00401

SM00439

SM00717

SM01189

TC14000836.hg

U35113

U35113_at

UPI000002AE69

UPI00003669FD

UPI0001611386

XM_011537305

XM_011537306

XM_011537308

XM_011537309

XM_011537310

XM_017021752

XM_017021753

XM_017021755

XM_017021756

XM_017021757

XM_017021758

XM_017021759

XP_011535607

XP_011535608

XP_011535610

XP_011535611

XP_011535612

XP_016877241

XP_016877242

XP_016877244

XP_016877245

XP_016877246

XP_016877247

XP_016877248

XR_001750593

Participant Of

input

PIAS1,3,4 SUMOylate MTA1 with SUMO2,3

hasMember

MTA1, MTA2, MTA3 [nucleoplasm]

Other forms of this molecule

SUMO2,3-K509-MTA1 [nucleoplasm]

Inferred To

MTA1 [nucleoplasm] (Bos taurus)

MTA1 [nucleoplasm] (Caenorhabditis elegans)

MTA1 [nucleoplasm] (Canis familiaris)

MTA1 [nucleoplasm] (Danio rerio)

MTA1 [nucleoplasm] (Dictyostelium discoideum)

MTA1 [nucleoplasm] (Gallus gallus)

MTA1 [nucleoplasm] (Rattus norvegicus)

MTA1 [nucleoplasm] (Sus scrofa)

MTA1 [nucleoplasm] (Xenopus tropicalis)

Mta1 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_001190187.1, NP_004680.2

OpenTargets

ENSG00000182979

GeneCards

Q13330

PRO

Q13330

PDB

5FXY, 4PC0, 6G16, 4PBZ, 5ICN, 4BKX, 4PBY

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	SUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030) HDAC1 [nucleoplasm] (R-HSA-205021)	0.905	11
UniProt:Q92769 HDAC2	2	SUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.802	5
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.766	8
UniProt:Q7Z3S9 NT2NA			0.696	5
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.666	4
UniProt:O60315 ZEB2			0.612	12
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.597	3
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [nucleoplasm] (R-HSA-450250) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.59	4
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.577	9
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.556	3
UniProt:Q6FGM0 Q6FGM0			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.556	6
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:Q5VWX1 KHDRBS2	2	p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031) KHDRBS2 [nucleoplasm] (R-HSA-8849028)	0.556	3
UniProt:O14519 CDKA1			0.527	2
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	3
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.527	4
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.488	2
UniProt:Q58EX7 PKHG4			0.488	2
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.488	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.488	2
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.488	2
UniProt:A8MQ03 CRTP1			0.488	2
UniProt:A2A935	1	PRDM16 [cytosol] (R-MMU-5634812)	0.462	2