Reactome | TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol]

Stable Identifier

R-HSA-3465532

Type

Complex

Species

Homo sapiens

Compartment

cytosol

GO Cellular Component

death-inducing signaling complex (0031264)

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
15024054	N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway Kataoka, T, Tschopp, J	Mol. Cell. Biol.	2004

Participants

components

Participant Of

output

FLIP(L) and procaspase-8 form heterodimer in TNF signaling

Inferred To

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Bos taurus)

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Danio rerio)

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Gallus gallus)

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Mus musculus)

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Sus scrofa)

TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Xenopus tropicalis)

© 2019 Reactome