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TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane]
Stable Identifier
R-HSA-3371390
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Death Receptors in the presence of ligand (Homo sapiens)
Regulation by c-FLIP (Homo sapiens)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Homo sapiens)
Participants
components
CASP8(1-479) [cytosol] (Homo sapiens)
CFLAR(1-480) [cytosol] (Homo sapiens)
TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Homo sapiens)
Participant Of
output
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling
Inferred To
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Bos taurus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Canis familiaris)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Danio rerio)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Gallus gallus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Mus musculus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Sus scrofa)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Xenopus tropicalis)
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