GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

Stable Identifier
R-HSA-3323079
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Glutathione reductase (GSR) in the mitochondrial matrix regenerates reduced glutathione from oxidized glutathione and NADPH (Berkholz et al. 2008).
Literature References
PubMed ID Title Journal Year
18638483 Catalytic cycle of human glutathione reductase near 1 A resolution

Savvides, SN, Berkholz, DS, Karplus, PA, Faber, HR

J. Mol. Biol. 2008
Participants
Participates
Catalyst Activity

glutathione-disulfide reductase (NADPH) activity of GSR dimer [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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