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XIAP dissociates from ub-TLE
Stable Identifier
R-HSA-3322434
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
XIAP dissociates from ub-TLE (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After ubiquitinating TLE, XIAP presumably dissociates. The model proposed by Hanson et al suggests the existence of an as-yet unidentified deubiquitinase that removes the ubiquitin from TLE to allow it to rebind to TCF/LEF.
Literature References
PubMed ID
Title
Journal
Year
22304967
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling
Beauchamp, RD
,
Freeman, TJ
,
Wallace, HA
,
Hanson, AJ
,
Lee, E
,
Lee, LA
Mol. Cell
2012
Participants
Input
ub-TLE:XIAP [nucleoplasm]
(Homo sapiens)
Output
ub-TLE [nucleoplasm]
(Homo sapiens)
XIAP [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
Orthologous Events
XIAP dissociates from ub-TLE (Bos taurus)
XIAP dissociates from ub-TLE (Canis familiaris)
XIAP dissociates from ub-TLE (Danio rerio)
XIAP dissociates from ub-TLE (Drosophila melanogaster)
XIAP dissociates from ub-TLE (Gallus gallus)
XIAP dissociates from ub-TLE (Mus musculus)
XIAP dissociates from ub-TLE (Rattus norvegicus)
XIAP dissociates from ub-TLE (Sus scrofa)
XIAP dissociates from ub-TLE (Xenopus tropicalis)
Authored
Rothfels, K (2013-05-30)
Reviewed
Rajakulendran, N (2014-01-22)
van Amerongen, R (2014-02-15)
Kikuchi, A (2014-04-22)
Created
Rothfels, K (2013-05-03)
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