Reactome | KAT5 [nucleoplasm]

KAT5 [nucleoplasm]

Stable Identifier

R-HSA-3321979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone acetyltransferase KAT5, KAT5_HUMAN, Tip60

Locations in the PathwayBrowser for interactor UniProt:Q9Y250 LZTS1

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External Reference Information

External Reference

UniProt:Q92993 KAT5

Gene Names

KAT5, HTATIP, TIP60

Chain

chain:1-513

Reference Genes

BioGPS Gene:10524 KAT5

COSMIC (genes):KAT5 KAT5

CTD Gene:10524 KAT5

dbSNP Gene:10524 KAT5

ENSEMBL:ENSG00000172977 KAT5

HGNC:5275 KAT5

KEGG Gene (Homo sapiens):10524 KAT5

Monarch:10524 KAT5

NCBI Gene:10524 KAT5

OMIM:601409 KAT5

UCSC:Q92993 KAT5

Reference Transcript

Other Identifiers

0006840167

0007000601

10524

11722613_a_at

16727045

16953

206689_x_at

209192_x_at

214258_x_at

2EKO

2OU2

3335520

3335521

3335522

3335523

3335524

3335526

3335527

3335530

3335533

3335534

3335535

3335536

3335538

3335541

3335542

3335546

3335549

3335551

3335552

3335553

465_at

4QQG

7941382

A0A024R597

A0A024R5E8

A_14_P100655

A_14_P136045

A_23_P138849

AAB02683

AAB18236

AAD00163

AAH00166

AAH64912

AAH93032

AAI17168

AAI43297

AAO21130

AK304664

AP001266

AY214165

BAG65439

BC000166

BC064912

BC093032

BC117167

BC143296

CCDS31610

CCDS55771

CCDS8109

CCDS8110

CH471076

E9PJI1

E9PMG8

E9PRL6

E9PRM3

EAW74427

EAW74428

EAW74429

EAW74430

EAW74432

ENSG00000172977

ENSP00000340330

ENSP00000344955

ENSP00000366245

ENSP00000434765

ENST00000341318

ENST00000341318.8

ENST00000352980

ENST00000352980.8

ENST00000377046

ENST00000377046.7

ENST00000530446

ENST00000530446.5

EntrezGene:10524

EntrezGene:KAT5

GE59393

GO:0000122

GO:0000123

GO:0000228

GO:0000729

GO:0000790

GO:0000812

GO:0003674

GO:0003713

GO:0004402

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0006259

GO:0006260

GO:0006302

GO:0006303

GO:0006325

GO:0006355

GO:0006464

GO:0006914

GO:0006950

GO:0006978

GO:0007165

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0010212

GO:0010485

GO:0010508

GO:0016032

GO:0016407

GO:0016573

GO:0016740

GO:0016746

GO:0018394

GO:0022607

GO:0030521

GO:0032703

GO:0032777

GO:0032991

GO:0034641

GO:0035267

GO:0040007

GO:0040008

GO:0042393

GO:0043161

GO:0043167

GO:0043226

GO:0043967

GO:0044403

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048471

GO:0050681

GO:0051276

GO:0061733

GO:0065003

GO:0070491

GO:0071392

GO:1901796

GO:1901985

GO:1904837

HGNC:5275

HPA016953

Hs.6364.4.A1_3p_a_at

HTATIP

ILMN_1724138

ILMN_1759789

ILMN_2414366

IPR000953

IPR002717

IPR016181

IPR016197

IPR025995

IPR036388

IPR037995

IPR040706

KAT5

KAT5-201

KAT5-202

KAT5-203

KAT5-208

MIM:601409

NM_001206833

NM_006388

NM_182709

NM_182710

NP_001193762

NP_006379

NP_874368

NP_874369

PF01853

PF11717

PF17772

PH_hs_0030021

SM00298

TC11000640.hg

U40989

U67734

U74667

U74667_at

UPI000000D8F9

UPI00000725C3

UPI00001D3EFB

UPI0000405B3F

XM_006718421

XP_006718484

XR_001747726

XR_001747727

XR_001747728

XR_002957116

Participant Of

hasMember

histone acetyltransferases [nucleoplasm]

hasComponent

output

input

Beta-catenin recruits TRRAP/KAT5 HAT components

Inferred To

KAT5 [nucleoplasm] (Bos taurus)

KAT5 [nucleoplasm] (Caenorhabditis elegans)

KAT5 [nucleoplasm] (Canis familiaris)

KAT5 [nucleoplasm] (Danio rerio)

KAT5 [nucleoplasm] (Dictyostelium discoideum)

KAT5 [nucleoplasm] (Drosophila melanogaster)

KAT5 [nucleoplasm] (Gallus gallus)

KAT5 [nucleoplasm] (Mus musculus)

KAT5 [nucleoplasm] (Plasmodium falciparum)

KAT5 [nucleoplasm] (Rattus norvegicus)

KAT5 [nucleoplasm] (Saccharomyces cerevisiae)

KAT5 [nucleoplasm] (Schizosaccharomyces pombe)

KAT5 [nucleoplasm] (Sus scrofa)

KAT5 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_874369.1, NP_006379.2, NP_001193762.1, NP_874368.1

OpenTargets

ENSG00000172977

IntEnz

2.3.1.48

ZINC - Substances

KAT5_HUMAN

GeneCards

Q92993

ZINC target

Q92993

ZINC - Biogenic

KAT5_HUMAN

PRO

Q92993

ZINC - Predictions - Purchasable

KAT5_HUMAN

HMDB Protein

HMDBP00036

PDB

2EKO, 4QQG, 2OU2

Interactors (103)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.758	5
UniProt:Q9NV56 MRGBP	1	MRGBP [nucleoplasm] (R-HSA-3322953)	0.737	6
UniProt:Q6NT76 HMBX1			0.696	5
UniProt:O75558 STX11			0.696	5
UniProt:Q9NQM4 PIHD3			0.696	5
UniProt:Q9UKT9 IKZF3			0.696	5
UniProt:Q9BRK4 LZTS2			0.696	5
UniProt:P11926 ODC1	1	PXLP-K69-ODC1 [cytosol] (R-HSA-70689)	0.696	5
UniProt:Q96BR9 ZBT8A			0.666	4
UniProt:Q96IK5 GMCL1			0.666	4
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.602	4
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.573	2
UniProt:P10085 Myod1	2	MYOD1 [nucleoplasm] (R-MMU-445441) MYOD1_MOUSE [nucleoplasm] (R-MMU-448840)	0.571	5
IntAct:EBI-15634422 H3K9-2			0.558	3
UniProt:Q15906 VPS72	1	VPS72 [nucleoplasm] (R-HSA-3321992)	0.558	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:P35711 SOX5			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q9NNX1 TUFT1			0.556	3
UniProt:Q8N8E2 ZN513			0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.556	3
UniProt:O75069-4 TMCC2			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.556	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q9Y2I6 NINL	2	NINL [cytosol] (R-HSA-380706) p-NINL [cytosol] (R-HSA-380716)	0.556	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.544	3
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.527	3
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	2
UniProt:Q92804 TAF15	1	TAF15 [nucleoplasm] (R-HSA-9020680)	0.524	2
UniProt:Q01844 EWS			0.524	2
UniProt:P54253 ATX1			0.524	3
UniProt:P03372-1 ESR1			0.524	3
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.524	2
UniProt:Q9P2H0 CE126			0.508	2
UniProt:O95257 GA45G			0.508	2
UniProt:O43261 LEU1			0.508	2
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.508	2
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.508	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.508	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.499	3
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.488	2
UniProt:Q6ZSJ9 SHSA6			0.488	2
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.488	2
UniProt:Q86Z20 CC125			0.488	2
UniProt:Q9BU19 ZNF692	1	ZNF692 [nucleoplasm] (R-HSA-2454144)	0.488	2
UniProt:O00213-2 APBB1			0.488	2
UniProt:Q96MP8-2 KCTD7			0.488	2
UniProt:Q8NB15-2 ZNF511			0.488	2
IntAct:EBI-11985505 KPNA5			0.488	2
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.488	2
UniProt:Q5JR59-3 MTUS2			0.488	2
UniProt:Q86WR7-2 PROSER2			0.488	2
UniProt:Q02535 ID3			0.488	2
UniProt:A0A0C3SFZ9 A0A0C3SFZ9			0.488	2
UniProt:Q8TF42 UBS3B			0.488	2
UniProt:Q9NQX0 PRDM6			0.488	2
UniProt:O75031 HSF2B			0.488	2
UniProt:Q9UM82 SPAT2			0.488	2
UniProt:Q53FD0-2 ZC2HC1C			0.488	2
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.488	2
UniProt:Q96BW1 UPP			0.488	2
UniProt:Q9NZ72 STMN3			0.488	2
UniProt:P23508 CRCM			0.488	2
UniProt:Q9Y250 LZTS1			0.488	2
UniProt:Q3B820 F161A			0.488	2
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.488	2
UniProt:Q96D03 DDT4L			0.488	2
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.488	2
UniProt:Q9BYV9 BACH2			0.488	2
UniProt:Q9H2F5-2 EPC1			0.488	2
UniProt:O75420 GGYF1			0.488	2
UniProt:Q96I34 PP16A			0.488	2
UniProt:Q96FV2 SCRN2			0.488	2
UniProt:P07910-2 HNRNPC			0.488	2
UniProt:Q9BW85 YJU2			0.488	2
UniProt:Q9Y2K1 ZBTB1			0.488	2
UniProt:Q5VSY0 GKAP1			0.488	2
UniProt:Q8TF50 ZN526			0.488	2
UniProt:Q15699 ALX1			0.488	2
IntAct:EBI-11957832 CCDC136			0.488	2
UniProt:Q8N680 ZBTB2			0.488	2
UniProt:Q8IY31-3 IFT20			0.488	2
UniProt:Q14140 SRTD2			0.488	2
UniProt:Q01101 INSM1	1	INSM1 [nucleoplasm] (R-HSA-210915)	0.488	2
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.488	2
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.488	2
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.488	2
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.488	2
UniProt:O60684 IMA7			0.488	2
UniProt:Q6NZI2 CAVIN1	1	PTRF [nucleoplasm] (R-HSA-74981)	0.488	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.488	2