Reactome | TAS2R5 [plasma membrane]

TAS2R5 [plasma membrane]

Stable Identifier

R-HSA-3299614

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 5, TA2R5_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYW4 TAS2R5

Gene Names

TAS2R5

Chain

chain:1-299

Reference Genes

BioGPS Gene:54429 TAS2R5

COSMIC (genes):TAS2R5 TAS2R5

CTD Gene:54429 TAS2R5

dbSNP Gene:54429 TAS2R5

ENSEMBL:ENSG00000127366 TAS2R5

ENSEMBL_homo_sapiens_GENE:ENSG00000127366.5 TAS2R5

HGNC:14912 TAS2R5

KEGG Gene (Homo sapiens):54429 TAS2R5

Monarch:54429 TAS2R5

NCBI Gene:54429 TAS2R5

OMIM:605062 TAS2R5

UCSC:Q9NYW4 TAS2R5

Reference Transcript

RefSeq:NM_018980.2 TAS2R5

Other Identifiers

11731877_s_at

17052421

231757_PM_at

231757_at

3027962

3027963

3027964

3027965

54429

8136647

A_14_P119964

A_23_P252100

GO:0001580

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007635

GO:0008527

GO:0016020

GO:0023052

GO:0033038

GO:0050877

GO:0050896

GO:0050909

GO:0060089

HMNXSV003007844

Hs.272388.0.S1_3p_at

ILMN_1752867

PH_hs_0026775

TC07000895.hg

Participates

as a member of

as a component of

TAS2R5:ligand [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

tas2r1a [plasma membrane] (Danio rerio)

Homologues of TAS2R19 [plasma membrane] (Danio rerio)

Homologues of TAS2R19 [plasma membrane] (Gallus gallus)

Homologues of TAS2R19 [plasma membrane] (Xenopus tropicalis)

TAS2R1b [plasma membrane] (Danio rerio)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

TAS2R5 [plasma membrane] (Canis familiaris)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_061853.1

Guide to Pharmacology - Targets

662

OpenTargets

ENSG00000127366

GeneCards

Q9NYW4

HPA

ENSG00000127366-TAS2R5

Ensembl

ENSG00000127366, ENST00000247883, ENSP00000247883

PRO

Q9NYW4

Pharos - Targets

Q9NYW4

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3