CBX4, UHRF2 SUMOylate ZNF131 with SUMO1

Stable Identifier
R-HSA-3296126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CBX4 (Pc2) and UHRF2 are able to SUMOylate ZNF131 on lysine-601 (lysine-567 in the isoform in Oh and Chung 2012, Oh and Chung 2013) . SUMOylation of ZNF131 increases the inhibition of ERalpha signaling by ZNF131 through suppression of ERalpha homodimerization.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of CBX4, UHRF2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created