PRMT5 binds WDR77

Stable Identifier
R-HSA-3215406
Type
Reaction [binding]
Species
Homo sapiens
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In mammalian cells, PRMT5 is tightly bound by WDR77 (MEP50). This interaction is required for PRMT5 activity (Friesen et al. 2002). The structure of PRMT5 and WDR77 (MEP50) was determined, bound to an S-adenosylmethionine analog and a peptide substrate derived from histone H4. The structure reveals a hetero-octameric complex formation, with close interaction between the seven-bladed beta-propeller WDR77 (MEP50) and the N-terminal domain of human PRMT5 (Antonysamy et al. 2012, Ho et al. 2013)

Literature References
PubMed ID Title Journal Year
11756452 A novel WD repeat protein component of the methylosome binds Sm proteins

Friesen, WJ, Wyce, A, Paushkin, S, Abel, L, Rappsilber, J, Mann, M, Dreyfuss, G

J. Biol. Chem. 2002
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