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KDM5A [nucleoplasm]
Stable Identifier
R-HSA-3215029
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Lysine-specific demethylase 5A, Histone demethylase JARID1A, Jumonji/ARID domain-containing protein 1A, Retinoblastoma-binding protein 2, RBBP-2, JARID1A, RBBP2, RBP2
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDMs demethylate histones (Homo sapiens)
KDM5A-D demethylate Me2K5-histone H3 (Homo sapiens)
KDM5A-D [nucleoplasm] (Homo sapiens)
KDM5A [nucleoplasm] (Homo sapiens)
KDM5A-D demethylate Me3K5-histone H3 (Homo sapiens)
KDM5A-D [nucleoplasm] (Homo sapiens)
KDM5A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Chromatin modifications during the maternal to zygotic transition (MZT) (Homo sapiens)
KDM5A demethylates histone H3 trimethyllysine-4 (H3K4me3) (Homo sapiens)
KDM5A:Fe2+ [nucleoplasm] (Homo sapiens)
KDM5A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29375 KDM5A
Gene Names
KDM5A, JARID1A, RBBP2, RBP2
Chain
chain:1-1690
Reference Genes
BioGPS Gene:5927 KDM5A
COSMIC (genes):KDM5A KDM5A
CTD Gene:5927 KDM5A
dbSNP Gene:5927 KDM5A
ENSEMBL:ENSG00000073614 KDM5A
ENSEMBL_homo_sapiens_GENE:ENSG00000073614.13 KDM5A
HGNC:9886 KDM5A
KEGG Gene (Homo sapiens):5927 KDM5A
Monarch:5927 KDM5A
NCBI Gene:5927 KDM5A
OMIM:180202 KDM5A
UCSC:P29375 KDM5A
Reference Transcript
RefSeq:NM_001042603.2 KDM5A
Other Identifiers
11739837_a_at
11739838_a_at
11743522_a_at
11743523_a_at
11743524_a_at
11743525_a_at
11755069_a_at
16759814
1785_at
202040_PM_s_at
202040_s_at
215698_PM_at
215698_at
226367_PM_at
226367_at
226371_PM_at
226371_at
230226_PM_s_at
230226_s_at
3439600
3439602
3439604
3439605
3439606
3439607
3439608
3439609
3439618
3439619
3439621
3439623
3439624
3439626
3439629
3439630
3439631
3439632
3439633
3439634
3439635
3439636
3439640
3439641
3439642
3439644
3439645
3439646
3439650
3439654
3439656
3439657
3439658
3439659
3439660
3439661
3439663
3439664
3439666
3439669
3439670
3439674
3439675
3439676
3439677
36999_at
54023_at
57505_at
5927
7960221
A_23_P204406
A_33_P3382748
GE56579
GE58789
GO:0000122
GO:0000785
GO:0000976
GO:0003677
GO:0003682
GO:0003713
GO:0003824
GO:0004857
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008270
GO:0016491
GO:0031490
GO:0032452
GO:0032453
GO:0032922
GO:0032993
GO:0034647
GO:0035064
GO:0036211
GO:0042393
GO:0043226
GO:0045893
GO:0046872
GO:0048511
GO:0051090
GO:0051213
GO:0098772
GO:0140096
GO:0140110
GO:0140718
GO:0141052
HMNXSV003007376
Hs.6567.0.S1_3p_a_at
Hs.6567.1.S1_3p_at
Hs.6567.1.S2_3p_at
Hs.76272.1.S1_3p_s_at
PH_hs_0004402
S66431_at
TC12001082.hg
TC12002701.hg
g4826967_3p_a_at
Participates
as a component of
KDM5A:Fe2+ [nucleoplasm] (Homo sapiens)
as a member of
KDM5A-D [nucleoplasm] (Homo sapiens)
Inferred To
KDM5A [nucleoplasm]
(Bos taurus)
KDM5A [nucleoplasm]
(Caenorhabditis elegans)
KDM5A [nucleoplasm]
(Canis familiaris)
KDM5A [nucleoplasm]
(Saccharomyces cerevisiae)
KDM5A [nucleoplasm]
(Schizosaccharomyces pombe)
KDM5A [nucleoplasm]
(Sus scrofa)
Kdm5a [nucleoplasm]
(Mus musculus)
Kdm5a [nucleoplasm]
(Rattus norvegicus)
rbbB [nucleoplasm]
(Dictyostelium discoideum)
Homologues of KDM5A [nucleoplasm]
(Schizosaccharomyces pombe)
lid2 [nucleoplasm]
(Schizosaccharomyces pombe)
msc1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001036068.1
Guide to Pharmacology - Targets
2680
OpenTargets
ENSG00000073614
HPA
ENSG00000073614-KDM5A
GeneCards
P29375
ZINC target
P29375
Ensembl
ENSG00000073614
,
ENSP00000382688
,
ENST00000399788
PRO
P29375
Pharos - Targets
P29375
Orphanet
24642
PDB
6DQ8
,
5IWF
,
5IVE
,
5V9P
,
6DQF
,
5IVB
,
6BH2
,
5IVC
,
6BH3
,
6DQ7
,
5E6H
,
5C11
,
6BGU
,
7KLO
,
5IVJ
,
5K4L
,
5CEH
,
6BH5
,
6BH4
,
5IVF
,
5V9T
,
6DQ9
,
6BGX
,
5ISL
,
6DQC
,
6BGW
,
7KLR
,
6DQB
,
6DQ4
,
5IW0
,
6BGV
,
6DQA
,
3GL6
,
6DQE
,
5IVY
,
2KGG
,
6BGZ
,
6DQ5
,
6DQ6
,
2JXJ
,
5IVV
,
6BGY
,
2KGI
,
6DQD
,
6BH0
,
6BH1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.499
2
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