Reactome | APH1A [plasma membrane]

APH1A [plasma membrane]

Stable Identifier

R-HSA-3211581

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-secretase subunit APH-1A, APH1A_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        gamma-secretase cleaves EPHB2 (Homo sapiens)
        
        gamma-secretase complex [plasma membrane] (Homo sapiens)
        
        APH-1 [plasma membrane] (Homo sapiens)
        
        APH1A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96BI3 APH1A

Gene Names

APH1A, PSF, CGI-78, UNQ579/PRO1141

Chain

chain:1-265

Reference Genes

BioGPS Gene:51107 APH1A

COSMIC (genes):APH1A APH1A

CTD Gene:51107 APH1A

dbSNP Gene:51107 APH1A

ENSEMBL:ENSG00000117362 APH1A

ENSEMBL_homo_sapiens_GENE:ENSG00000117362.13 APH1A

HGNC:29509 APH1A

KEGG Gene (Homo sapiens):51107 APH1A

Monarch:51107 APH1A

NCBI Gene:51107 APH1A

OMIM:607629 APH1A

UCSC:Q96BI3 APH1A

Reference Transcript

Other Identifiers

11718148_a_at

11718149_x_at

11744723_a_at

11745996_x_at

11749882_x_at

11763721_x_at

11764017_x_at

1554417_PM_s_at

1554417_s_at

16692741

218389_PM_s_at

218389_s_at

237327_PM_at

237327_at

2434342

2434343

2434344

2434345

2434346

2434347

2434349

2434351

2434352

2434354

2434355

2434356

2434358

2434359

2434360

2434361

2434362

2434363

51107

56395_at

64290_at

7919729

85902_at

A_23_P12329

A_23_P930

GE58654

GE86437

GO:0000139

GO:0001656

GO:0005515

GO:0005768

GO:0005769

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006509

GO:0007219

GO:0007220

GO:0008021

GO:0010008

GO:0010950

GO:0016020

GO:0016485

GO:0019899

GO:0023052

GO:0030674

GO:0031293

GO:0031410

GO:0032580

GO:0034205

GO:0042734

GO:0042982

GO:0042987

GO:0043085

GO:0043226

GO:0048856

GO:0051604

GO:0060090

GO:0061133

GO:0070765

GO:0097060

GO:0098772

HMNXSV003009818

Hs.192491.0.A1_3p_at

Hs2.108408.3.S1_3p_s_at

ILMN_1658472

ILMN_2398388

PH_hs_0006004

TC01003201.hg

TC01005811.hg

g7705786_3p_s_at

Participates

as a member of

APH-1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

APH1A [endosome membrane]

Inferred To

APH1A [plasma membrane] (Bos taurus)

APH1A [plasma membrane] (Canis familiaris)

APH1A [plasma membrane] (Danio rerio)

APH1A [plasma membrane] (Gallus gallus)

APH1A [plasma membrane] (Sus scrofa)

Aph1a [plasma membrane] (Mus musculus)

Aph1a [plasma membrane] (Rattus norvegicus)

aph1a [plasma membrane] (Xenopus tropicalis)

aph-1 [plasma membrane] (Caenorhabditis elegans)

aph-1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001230700.1, NP_001230701.1, NP_001071096.1, NP_057106.2

OpenTargets

ENSG00000117362

GeneCards

Q96BI3

HPA

ENSG00000117362-APH1A

Ensembl

ENSP00000397473, ENSG00000117362, ENST00000360244, ENSP00000358105, ENST00000414276, ENSP00000353380, ENST00000369109

PRO

Q96BI3

Pharos - Targets

Q96BI3

PDB

5FN2, 7Y5T, 6IDF, 6LQG, 5A63, 7C9I, 6LR4, 7Y5Z, 7Y5X, 5FN5, 5FN3, 7D8X, 6IYC, 5FN4

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478) IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3