The mechanisms that control β-catenin localization are not fully elucidated. β-catenin transport to the nucleus is thought to occur in a NLS (nuclear localization signal)- and importin-independent manner through direct interaction with the nuclear pore complex (NPC) components. This has been shown to be the case for Wnt-signaling in mammalian cells (Yokoya F et al. 1999; Koike M et al. 2004). β-catenin may also 'piggy-back' into the nucleus in complex with other proteins such as FOXM1 (Zhang N et al., 2011 ) or BCL9 (Townsley FM et al., 2004).
Taniguchi, N, Imamoto, N, Koike, M, Furuta, M, Yokoya, F, Kose, S, Yoneda, Y
Wen, M, Rui, Y, Liu, X, Yang, P, Cao, X, Zheng, Y, An, H
© 2024 Reactome
