PRC1 SUMOylates CTBP1 with SUMO1

Stable Identifier
R-HSA-3108209
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CBX4 (Pc2) via its SUMO-interacting motifs recruits both CTBP1 and SUMO1:UBE2I (SUMO1:UBC9) to polycomb bodies where CTBP1 is SUMOylated with SUMO1 at lysine-428 (Kagey et al. 2003, Merrill et al. 2010, Yang and Sharrocks 2010).

Literature References
PubMed ID Title Journal Year
12679040 The polycomb protein Pc2 is a SUMO E3

Kagey, MH, Melhuish, TA, Wotton, D

Cell 2003
20176810 The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif

Yang, SH, Sharrocks, AD

Mol. Cell. Biol. 2010
20098713 A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity

Merrill, JC, Melhuish, TA, Kagey, MH, Yang, SH, Sharrocks, AD, Wotton, D

PLoS ONE 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PRC1 complex [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created