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MBD4 [nucleoplasm]
Stable Identifier
R-HSA-3006633
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MBD4 glycosylase, Methyl-CpG-binding domain protein 4, MBD4_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
Cleavage of thymine by MBD4 glycosylase (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4:CpG(T:G)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
Cleavage of uracil by MBD4 glycosylase (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4:CpG(U:G)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4:CpG(T:G)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4:CpG(U:G)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
Resolution of Abasic Sites (AP sites) (Homo sapiens)
Displacement of DNA glycosylase by APEX1 (Homo sapiens)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95243 MBD4
Gene Names
MBD4, MED1
Chain
chain:1-580
Reference Genes
BioGPS Gene:8930 MBD4
COSMIC (genes):MBD4 MBD4
CTD Gene:8930 MBD4
dbSNP Gene:8930 MBD4
ENSEMBL:ENSG00000129071 MBD4
ENSEMBL_homo_sapiens_GENE:ENSG00000129071.10 MBD4
HGNC:6919 MBD4
KEGG Gene (Homo sapiens):8930 MBD4
Monarch:8930 MBD4
NCBI Gene:8930 MBD4
OMIM:603574 MBD4
UCSC:O95243 MBD4
Reference Transcript
RefSeq:NM_001276270.1 MBD4
RefSeq:NM_001276273.1 MBD4
RefSeq:NM_001276271.1 MBD4
RefSeq:NM_001276272.1 MBD4
RefSeq:NM_003925.2 MBD4
Other Identifiers
11719798_s_at
11719799_a_at
11756936_a_at
11760224_at
16958989
209579_PM_s_at
209579_s_at
209580_PM_s_at
209580_s_at
214047_PM_s_at
214047_s_at
2694749
2694786
2694787
2694788
2694789
2694791
2694792
2694793
2694794
2694796
2694798
2694800
2694801
2694802
2694803
2694804
2694805
2694806
2694807
2694808
2694809
2694810
34386_at
8090577
8930
A_23_P92154
GE54678
GO:0003677
GO:0003696
GO:0003824
GO:0004520
GO:0005515
GO:0005634
GO:0005654
GO:0006281
GO:0006974
GO:0008263
GO:0016607
GO:0016787
GO:0019104
GO:0032355
GO:0043226
GO:0045008
GO:0055086
GO:0140097
GO:1901135
HMNXSV003003936
HMNXSV003021796
Hs.35947.0.S1_3p_a_at
Hs.35947.1.S1_3p_a_at
ILMN_2055310
PH_hs_0002885
TC03001771.hg
Participates
as an output of
Displacement of MBD4 glycosylase by APEX1 at the AP site (Homo sapiens)
as an input of
MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences (Homo sapiens)
MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences (Homo sapiens)
as a component of
MBD4:CpG(T:G)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4:CpG(AP)-dsDNA [nucleoplasm] (Homo sapiens)
MBD4:CpG(U:G)-dsDNA [nucleoplasm] (Homo sapiens)
Inferred To
Mbd4 [nucleoplasm]
(Mus musculus)
Mbd4 [nucleoplasm]
(Rattus norvegicus)
MBD4 [nucleoplasm]
(Bos taurus)
MBD4 [nucleoplasm]
(Canis familiaris)
MBD4 [nucleoplasm]
(Gallus gallus)
MBD4 [nucleoplasm]
(Sus scrofa)
mbd4 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001263201.1
,
NP_001263200.1
,
NP_001263202.1
,
NP_003916.1
,
NP_001263199.1
OpenTargets
ENSG00000129071
HPA
ENSG00000129071-MBD4
GeneCards
O95243
Ensembl
ENSP00000424873
,
ENSP00000376959
,
ENSP00000249910
,
ENST00000429544
,
ENSP00000394080
,
ENST00000507208
,
ENST00000249910
,
ENSP00000422327
,
ENST00000393278
,
ENSG00000129071
,
ENST00000503197
PRO
O95243
Pharos - Targets
O95243
PDB
4OFH
,
4LG7
,
4OFE
,
3IHO
,
4EA5
,
4OFA
,
7KZG
,
7KZ1
,
4EA4
,
4E9G
,
4E9H
,
5CHZ
,
4E9E
,
4DK9
,
7KZ0
,
4E9F
,
2MOE
,
6VJW
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.581
6
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.553
2
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