RANBP2 SUMOylates SP100 with SUMO1

Stable Identifier
R-HSA-3000399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to SP100
Locations in the PathwayBrowser
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RANBP2 SUMOylates SP100 with SUMO1 at lysine-297 (Pichler et al. 2002, Tatham et al. 2005). RANBP2 has a binding site for SUMO1 and a binding site for UBE2I (UBC9) which may recruit the SUMO1:UBE2I (SUMO1:UBC9) complex (Tatham et al. 2005). RANBP2 is located on the cytoplasmic filaments of the nuclear pore so that SUMOylation may occur during nuclear import of SP100 (Pichler et al. 2002)

Literature References
PubMed ID Title Journal Year
11792325 The nucleoporin RanBP2 has SUMO1 E3 ligase activity

Pichler, A, Gast, A, Seeler, JS, Dejean, A, Melchior, F

Cell 2002
18691969 Ubc9 sumoylation regulates SUMO target discrimination

Knipscheer, P, Flotho, A, Klug, H, Olsen, JV, van Dijk, WJ, Fish, A, Johnson, ES, Mann, M, Sixma, TK, Pichler, A

Mol. Cell 2008
15608651 Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

Tatham, MH, Kim, S, Jaffray, E, Song, J, Chen, Y, Hay, RT

Nat. Struct. Mol. Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created