MDM2 SUMOylates TP53 with SUMO2,3

Stable Identifier
R-HSA-2997706
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Conjugation of SUMO2,3 to TP53
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MDM2 SUMOylates TP53 with SUMO2,3
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MDM2 in a complex with CDKN2A (p14-ARF) SUMOylates TP53 (p53) with SUMO2,3 at lysine-386 (Stindt et al. 2011, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation decreases transcriptional activation by TP53 at some genes and decreases repression by TP53 at other genes (Stindt et al. 2011).

Literature References
PubMed ID Title Journal Year
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
21900752 MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

Stindt, MH, Carter, S, Vigneron, AM, Ryan, KM, Vousden, KH

Cell Cycle 2011
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of p14-ARF:MDM2 [nucleoplasm]
Physical Entity
p14-ARF:MDM2 [nucleoplasm]
Activity
SUMO transferase activity (0019789)
Authored
May, B  (2013-01-19)
Reviewed
Vousden, KH  (2016-01-07)
Created
May, B  (2013-01-24)