Reactome | CXCR4 [plasma membrane]

CXCR4 [plasma membrane]

Stable Identifier

R-HSA-2980772

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-X-C chemokine receptor type 4, CXCR4_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Early Phase of HIV Life Cycle (Homo sapiens)
        
        Binding and entry of HIV virion (Homo sapiens)
        
        CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4 (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Conformational changes in gp120 exposes gp41 (Homo sapiens)
        
        Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Fusion of viral membrane with host cell membrane (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Fusogenic activation of gp41 (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 exposed [extracellular region] (Homo sapiens)
        
        CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Insertion of gp41 fusion peptide into the target membrane (Homo sapiens)
        
        Virion with fusogenically activated gp41 [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        N and C terminal heptad repeat helices of gp41 form six-helix bundle (Homo sapiens)
        
        Virion with gp41 forming hairpin structure [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Virion with gp41 fusion peptide in insertion complex [extracellular region] (Homo sapiens)
        
        CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane] (Homo sapiens)
        
        CCR5, CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CXCR4 and 7 bind CXCL12 ligand (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)
        
        CXCR4,7:CXCL12 [plasma membrane] (Homo sapiens)
        
        CXCR4,7 [plasma membrane] (Homo sapiens)
        
        CXCR4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61073 CXCR4

Gene Names

CXCR4, LAP-3

Chain

chain:1-352

Reference Genes

BioGPS Gene:7852 CXCR4

COSMIC (genes):CXCR4 CXCR4

CTD Gene:7852 CXCR4

dbSNP Gene:7852 CXCR4

ENSEMBL:ENSG00000121966 CXCR4

ENSEMBL_homo_sapiens_GENE:ENSG00000121966.8 CXCR4

HGNC:2561 CXCR4

KEGG Gene (Homo sapiens):7852 CXCR4

Monarch:7852 CXCR4

NCBI Gene:7852 CXCR4

OMIM:162643 CXCR4

UCSC:P61073 CXCR4

Reference Transcript

Other Identifiers

11728189_a_at

11728190_s_at

11728191_x_at

11739094_a_at

16903140

209201_3p_x_at

209201_PM_x_at

209201_x_at

211919_PM_s_at

211919_s_at

217028_PM_at

217028_at

2578041

2578042

2578043

2578044

2578045

2578046

2578047

2578052

649_s_at

7852

8055465

A_23_P102000

GE54062

GO:0001618

GO:0001666

GO:0001764

GO:0002064

GO:0002376

GO:0002407

GO:0003012

GO:0003013

GO:0003779

GO:0004930

GO:0004950

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005886

GO:0006915

GO:0006935

GO:0006954

GO:0006955

GO:0007155

GO:0007165

GO:0007186

GO:0007204

GO:0007420

GO:0008038

GO:0008092

GO:0009615

GO:0009897

GO:0009986

GO:0012501

GO:0014070

GO:0014823

GO:0015026

GO:0016020

GO:0016477

GO:0016493

GO:0016494

GO:0019722

GO:0019955

GO:0019957

GO:0022008

GO:0022029

GO:0023052

GO:0030154

GO:0030155

GO:0030335

GO:0031252

GO:0031410

GO:0031625

GO:0032027

GO:0032991

GO:0035470

GO:0036094

GO:0038147

GO:0038160

GO:0042060

GO:0043067

GO:0043130

GO:0043217

GO:0043226

GO:0045446

GO:0046718

GO:0048714

GO:0048856

GO:0048870

GO:0050769

GO:0050792

GO:0050877

GO:0050920

GO:0050921

GO:0050965

GO:0050966

GO:0051924

GO:0060048

GO:0060089

GO:0060326

GO:0061024

GO:0061154

GO:0070062

GO:0070098

GO:0070161

GO:0071345

GO:0071417

GO:0071466

GO:0120162

GO:1901327

GO:1903861

GO:1904018

GO:1905322

GO:1990478

GO:2000448

HMNXSV003031179

Hs.89414.1.S1_3p_at

ILMN_1801584

ILMN_2246410

ILMN_2320888

L06797_s_at

PH_hs_0019757

TC02002378.hg

g13549089_3p_s_at

g189313_3p_a_at

Participates

as an output of

as a member of

as a component of

CXCR4:CXCL12 [plasma membrane] (Homo sapiens)

Inferred To

npr-32 [plasma membrane] (Caenorhabditis elegans)

cxcr4 [plasma membrane] (Xenopus tropicalis)

CXCR4 [plasma membrane] (Bos taurus)

CXCR4 [plasma membrane] (Canis familiaris)

CXCR4 [plasma membrane] (Gallus gallus)

CXCR4 [plasma membrane] (Sus scrofa)

Cxcr4 [plasma membrane] (Mus musculus)

Cxcr4 [plasma membrane] (Rattus norvegicus)

cb824 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_003458.1, NP_001334989.1, NP_001334985.1, NP_001008540.1, NP_001334988.1

ZINC - World Drugs

CXCR4_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000121966

ZINC - FDA approved

CXCR4_HUMAN

ZINC - Substances

CXCR4_HUMAN

ZINC target

P61073

PRO

P61073

PDB

8I0Q, 3OE9, 4RWS, 3OE8, 2K05, 3ODU, 2K03, 3OE6, 3OE0, 2N55, 2K04, 8GP3

ZINC - Investigational

CXCR4_HUMAN

HPA

ENSG00000121966-CXCR4

GeneCards

P61073

Ensembl

ENST00000409817, ENST00000241393, ENSP00000241393, ENSG00000121966, ENSP00000386884

Pharos - Targets

P61073

Orphanet

15827

ZINC - Predictions - Purchasable

CXCR4_HUMAN

HMDB Protein

HMDBP07643

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25106 ACKR3	1	CXCR7 [plasma membrane] (R-HSA-373859)	0.853	18
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.702	5
UniProt:P51681 CCR5	1	CCR5 [plasma membrane] (R-HSA-171279)	0.675	4
UniProt:P35368 ADRA1B	1	ADRA1B [plasma membrane] (R-HSA-390661)	0.606	9
UniProt:P35348 ADRA1A	1	ADRA1A [plasma membrane] (R-HSA-390669)	0.606	10
UniProt:O60603 TLR2	3	TLR2 [plasma membrane] (R-HSA-9637646) TLR2 [secretory granule membrane] (R-HSA-6804777) TLR2 [plasma membrane] (R-HSA-167992)	0.59	3
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.556	4
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.556	5
UniProt:Q07266-1 DBN1			0.556	3
UniProt:Q96J02-2 ITCH			0.537	3
UniProt:P49682 CXCR3	1	CXCR3 [plasma membrane] (R-HSA-2980699)	0.512	5
UniProt:Q04900 MUC24			0.499	2

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