Reactome | CRK [cytosol]

CRK [cytosol]

Stable Identifier

R-HSA-2980677

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Adapter molecule crk, CRK_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P29353 SHC1

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin signaling (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        CRK [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46108 CRK

Gene Names

CRK

Chain

initiator methionine:1, chain:2-304

Reference Genes

BioGPS Gene:1398 CRK

COSMIC (genes):CRK CRK

CTD Gene:1398 CRK

dbSNP Gene:1398 CRK

ENSEMBL:ENSG00000167193 CRK

HGNC:2362 CRK

KEGG Gene (Homo sapiens):1398 CRK

Monarch:1398 CRK

NCBI Gene:1398 CRK

OMIM:164762 CRK

UCSC:P46108 CRK

Reference Transcript

Other Identifiers

0005360338

0005360446

0104810131

10485

11725320_x_at

11725321_a_at

11736647_s_at

1398

16839345

1JU5

202224_at

202225_at

202226_s_at

2DVJ

2EYV

2EYW

2EYX

2EYY

2EYZ

2MS4

3205250

3740172

3740173

3740174

3740175

3740177

3740178

3740179

3740180

3740181

38219_at

49090_at

5UL6

68087

6ATV

772_at

8011018

A0A0S2Z3K9

A0A0S2Z3Q4

A_23_P83556

A_24_P270814

AAB28213

AAH01718

AAH08506

AAH09837

AAP35941

ABY87527

AC032044

AC100748

AGC09588

AK291060

ALQ33454

ALQ33455

BAA01505

BAF83749

BC001718

BC008506

BC009837

BT007277

CAB010485

CCDS11002

CCDS45561

CH471108

CRK

CRK-201

CRK-202

D10656

D10656_at

EAW90621

EAW90624

EAW90625

ENSG00000167193

ENSP00000300574

ENSP00000381942

ENST00000300574

ENST00000300574.2

ENST00000398970

ENST00000398970.5

EntrezGene:1398

EntrezGene:CRK

EU332838

g8400705_3p_a_at

GE57045

GO:0000186

GO:0000902

GO:0001764

GO:0001784

GO:0001878

GO:0002376

GO:0002685

GO:0003674

GO:0005070

GO:0005159

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006357

GO:0006464

GO:0006629

GO:0006810

GO:0006950

GO:0007010

GO:0007155

GO:0007165

GO:0008092

GO:0008150

GO:0008360

GO:0009058

GO:0009966

GO:0009967

GO:0014911

GO:0015629

GO:0016020

GO:0016192

GO:0016358

GO:0017124

GO:0019221

GO:0019899

GO:0019904

GO:0021766

GO:0021987

GO:0030010

GO:0030154

GO:0030674

GO:0032956

GO:0032991

GO:0033628

GO:0034641

GO:0035020

GO:0035685

GO:0035728

GO:0038026

GO:0038096

GO:0040011

GO:0042169

GO:0042542

GO:0043087

GO:0043226

GO:0043393

GO:0043621

GO:0045121

GO:0045309

GO:0045953

GO:0046875

GO:0048010

GO:0048013

GO:0048856

GO:0048870

GO:0050773

GO:0060326

GO:0061045

GO:0061847

GO:0070062

GO:0071560

GO:0071732

GO:0090630

GO:0097110

GO:0098749

GO:1900026

GO:1901652

GO:1990090

GO:1990314

GO:1990782

GO:1990859

GO:2000146

GO:2000404

HGNC:2362

HPA068087

Hs.306088.0.A2_3p_at

Hs.306088.0.A3_3p_at

I3L297

ILMN_1666494

ILMN_1686805

ILMN_1803302

IPR000980

IPR001452

IPR035457

IPR035458

IPR036028

IPR036860

JX512441

KU177996

KU177997

L7RT18

MIM:164762

NM_005206

NM_016823

NP_005197

NP_058431

PF00017

PF00018

PF07653

PH_hs_0016623

PH_hs_0026639

PR00401

PR00452

S65701

SM00252

SM00326

TC17000973.hg

TC17002435.hg

UPI0000071225

UPI000007290B

Participant Of

hasComponent

input

hasMember

CRK, CRKL [cytosol]

Inferred To

Ghost homologue of CRK [cytosol] (Dictyostelium discoideum)

CRK [cytosol] (Bos taurus)

CRK [cytosol] (Caenorhabditis elegans)

CRK [cytosol] (Canis familiaris)

CRK [cytosol] (Danio rerio)

CRK [cytosol] (Drosophila melanogaster)

CRK [cytosol] (Gallus gallus)

CRK [cytosol] (Mus musculus)

CRK [cytosol] (Rattus norvegicus)

CRK [cytosol] (Sus scrofa)

CRK [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005197.3, NP_058431.2

OpenTargets

ENSG00000167193

GeneCards

P46108

PRO

P46108

PDB

2EYX, 2EYV, 2EYZ, 5UL6, 6ATV, 1JU5, 2DVJ, 2MS4, 2EYY, 2EYW

Interactors (59)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	6	p-Y371-CBL [plasma membrane] (R-HSA-182923) p-Y-CBL [cytosol] (R-HSA-8875457) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940)	0.878	10
UniProt:Q70EK8 UBP53			0.781	10
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723)	0.764	5
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.764	9
UniProt:P16234 PDGFRA	2	PDGFRA [plasma membrane] (R-HSA-186794) p-11Y-PDGFRA [plasma membrane] (R-HSA-186806)	0.708	4
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.702	5
UniProt:Q8TDY4 ASAP3			0.697	5
UniProt:Q07889 SOS1	3	SOS1 [plasma membrane] (R-HSA-983559) p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [cytosol] (R-HSA-64847)	0.688	3
UniProt:Q13905 RAPGEF1	3	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [cytosol] (R-HSA-3008672) RAPGEF1 [endosome] (R-HSA-3008667)	0.688	4
UniProt:Q8ND30 PPFIBP2	1	PPFIBP2 [cytosol] (R-HSA-6799320)	0.666	4
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.666	4
UniProt:Q9Y4K4 M4K5			0.641	5
UniProt:P54253 ATX1			0.635	3
UniProt:Q05397 PTK2	11	PTK2(773-1052) [cytosol] (R-HSA-202829) pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(1-772) [cytosol] (R-HSA-202827) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.635	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.621	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.621	4
UniProt:P41970 ELK3			0.601	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.592	3
UniProt:P10721 KIT	4	p-S741,S746-KIT [plasma membrane] (R-HSA-1433492) p-8Y-KIT [plasma membrane] (R-HSA-1472116) KIT [plasma membrane] (R-HSA-197662) p-7Y-KIT [plasma membrane] (R-HSA-205207)	0.59	4
UniProt:P45983 MAPK8	3	p-T,Y-MAPK8 [cytosol] (R-HSA-194371) MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.589	2
UniProt:Q92918 M4K1			0.589	3
UniProt:P21333 FLNA	3	p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019) FLNA [extracellular region] (R-HSA-350712)	0.589	3
UniProt:Q8TB24 RIN3	1	RIN3 [cytosol] (R-HSA-8875292)	0.573	2
UniProt:P11362 FGFR1	8	FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361)	0.564	2
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.564	2
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.564	2
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.564	3
UniProt:P00519 ABL1	5	ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.564	2
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q96Q35-2 FLACC1			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.543	3
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.508	2
UniProt:O40931 O40931			0.499	2
UniProt:O13016 PTN1			0.489	2
UniProt:Q9H706 GARE1			0.488	2
UniProt:Q8WZ19 BACD1			0.488	2
UniProt:Q08AM6 VAC14	3	VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219) VAC14 [Golgi membrane] (R-HSA-1806235)	0.488	2
UniProt:Q12841 FSTL1	3	p-FSTL1 [endoplasmic reticulum lumen] (R-HSA-8957089) FSTL1 [extracellular region] (R-HSA-201832) FSTL1 [endoplasmic reticulum lumen] (R-HSA-8956749)	0.488	2
UniProt:Q99645 EPYC			0.488	2
UniProt:P29372-4 MPG			0.488	2
UniProt:P27986-2 PIK3R1			0.488	2
UniProt:P42684-3 ABL2			0.488	2
UniProt:P19419 ELK1	2	p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350) ELK1 [nucleoplasm] (R-HSA-3009346)	0.488	2
UniProt:Q9Y3I0 RTCB	1	RTCB [nucleoplasm] (R-HSA-5696792)	0.488	2
UniProt:Q14847 LASP1			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
UniProt:Q14765 STAT4	4	p-STAT4 [cytosol] (R-HSA-8950350) p-Y693-STAT4 [nucleoplasm] (R-HSA-8950636) p-Y693-STAT4 [cytosol] (R-HSA-8950343) STAT4 [cytosol] (R-HSA-8950606)	0.488	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:P42681 TXK	3	p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) TXK [cytosol] (R-HSA-3448733) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.488	2
UniProt:O14669 TMG2			0.488	2
UniProt:Q8N448 LNX2			0.488	2
UniProt:Q92854 SEMA4D	1	SEMA4D [plasma membrane] (R-HSA-197744)	0.488	2
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.488	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:O14654 IRS4	2	IRS4 [plasma membrane] (R-HSA-2424297) p-Y-IRS4 [plasma membrane] (R-HSA-2424302)	0.462	8
UniProt:A9UF07 A9UF07			0.462	4