Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ARHGEF4 [cytosol]
Stable Identifier
R-HSA-2976635
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 4, ARHG4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NR80 ARHGEF4
Gene Names
ARHGEF4, KIAA1112
Chain
chain:1-690
Reference Genes
BioGPS Gene:50649 ARHGEF4
COSMIC (genes):ARHGEF4 ARHGEF4
CTD Gene:50649 ARHGEF4
dbSNP Gene:50649 ARHGEF4
ENSEMBL:ENSG00000136002 ARHGEF4
ENSEMBL_homo_sapiens_GENE:ENSG00000136002.21 ARHGEF4
HGNC:684 ARHGEF4
KEGG Gene (Homo sapiens):50649 ARHGEF4
Monarch:50649 ARHGEF4
NCBI Gene:50649 ARHGEF4
OMIM:605216 ARHGEF4
UCSC:Q9NR80 ARHGEF4
Reference Transcript
RefSeq:NM_015320.3 ARHGEF4
RefSeq:NM_032995.2 ARHGEF4
Other Identifiers
11725181_a_at
11750910_a_at
11752534_x_at
11752699_a_at
16885638
205109_PM_s_at
205109_s_at
211891_PM_s_at
211891_s_at
2505858
2505859
2505860
2505862
2505864
2505865
2505866
2505887
2505889
2505906
2505908
2505909
2505911
2505913
2505914
2505918
2505919
2505920
2505923
2505924
2505925
2505926
2505927
2505928
2505929
2505930
36524_at
41527_f_at
50649
8045229
A_14_P120614
A_14_P136759
A_23_P253221
A_24_P302685
A_33_P3233099
GE53752
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0016020
GO:0019904
GO:0023052
GO:0030032
GO:0032587
GO:0035556
GO:0042995
GO:0046847
GO:0051056
GO:0098772
HMNXSV003039342
HMNXSV003047262
ILMN_1666076
ILMN_2342282
PH_hs_0000610
PH_hs_0030925
g9558722_3p_a_at
g9857317_3p_a_at
g9857317_3p_x_at
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
as a member of
CDC42 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_127462.1
,
NP_056135.2
OpenTargets
ENSG00000136002
HPA
ENSG00000136002-ARHGEF4
GeneCards
Q9NR80
Ensembl
ENSG00000136002
,
ENSP00000316845
,
ENSP00000348017
,
ENST00000326016
,
ENST00000355771
PRO
Q9NR80
Pharos - Targets
Q9NR80
Orphanet
29610
HMDB Protein
HMDBP11493
PDB
2PZ1
,
3NMZ
,
2DX1
,
3NMX
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text