Reactome | Autophosphorylation of PKC-theta

Autophosphorylation of PKC-theta

Stable Identifier

R-HSA-2730835

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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T219, T538 at the activation loop, S676 at the turn motif and S695 at the hydrophobic motif are autophosphorylated in cis-maanner. Posphorylation of T538 is critical for kinase activation and it stabilises the open active conformation. Some studies suggest the involvement of PDK1 (3-phosphoinositide-dependent protein kinase 1) and GLK kinases in the phosphorylation T538.

Literature References

PubMed ID	Title	Journal	Year
22798961	Regulation of PKC-? function by phosphorylation in T cell receptor signaling Tan, TH, Chuang, HC, Wang, X, Li, JP	Front Immunol	2012
11772397	Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction Li, A, Liu, Y, Shaw, S, Graham, C, Fisher, RJ	Biochem. J.	2002
16252004	Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes Baier, G, Bauer, B, Fresser, F, Heit, I, Dammeier, S, Copeland, TD, Graham, C, Thuille, N, Shaw, S, Leuthaeusser, S, Krumböck, N	EMBO J.	2005