Reactome | Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2

Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2

Stable Identifier

R-HSA-2671873

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2

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SH2B1 in the LEP:LEPR:JAK2:SH2B1 complex can bind either IRS1 or IRS2 (Duan et al. 2004, Li et al. 2007). The binding brings IRS1/2 into proximity with JAK2 for phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
15316008	SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin Duan, C, Li, M, Rui, L	J Biol Chem	2004
17565041	SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms Li, Z, Zhou, Y, Carter-Su, C, Rui, L, Myers, MG	Mol. Endocrinol.	2007

Participants

Input

Output

LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] (Homo sapiens)

Participates

as an event of

Signaling by Leptin (Homo sapiens)

Inferred From

Phosphorylated Lep:Lepr:Jak2:Sh2b1 Binds Irs1/2 (Mus musculus)

Authored

May, B (2012-11-24)

Reviewed

Scherer, T (2013-08-31)

Gonzalez-Perez, RR (2013-10-26)

Created

May, B (2012-11-26)

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