Phosphorylated LEP:LEPR:JAK2 Binds SH2B1

Stable Identifier
R-HSA-2671872
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

The SH2 domain of SH2B1 binds phosphotyrosine-813 of JAK2 (Nishi et al. 2005, Li et al. 2007). Binding of SH2B1 to JAK2 enhances leptin-induced JAK2 activity. SH2B1 also recruits IRS1 for phosphorylation by JAK2 (Li et al. 2007).

Literature References
PubMed ID Title Journal Year
17565041 SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms

Li, Z, Zhou, Y, Carter-Su, C, Myers, MG, Rui, L

Mol. Endocrinol. 2007
15767667 Kinase activation through dimerization by human SH2-B

Nishi, M, Werner, ED, Oh, BC, Frantz, JD, Dhe-Paganon, S, Hansen, L, Lee, J, Shoelson, SE

Mol Cell Biol 2005
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