Phosphorylated LEPR Binds STAT3

Stable Identifier
R-HSA-2671868
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

STAT3 binds phosphotyrosine-1141 of the C-terminal, cytoplasmic region of LEPR (Bjorbaek et al. 1997). Only the long isoform of LEPR has tyrosine-1141 and consequently only the long isoform of LEPR activates STAT3. Short isoforms of LEPR exist but their function is uncertain. Shorter LEPR isoforms bind JAK2 and can signal through IRS-1 or ERKs, including MAPKs (Bjorbaek et al. 1997).

Literature References
PubMed ID Title Journal Year
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor J. Biol. Chem. 1997
Participants
Participant Of
Inferred From