JAK2 Phosphoryates STAT3 in Response to Leptin

Stable Identifier
R-HSA-2671850
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated JAK2 in the LEP:LEPR:JAK2:STAT3 complex phosphorylates STAT3 at tyrosine-705 (Bjorbaek et al. 1997).

Literature References
PubMed ID Title Journal Year
9405487 Divergent signaling capacities of the long and short isoforms of the leptin receptor

Bjørbaek, C, Uotani, S, da Silva, B, Flier, JS

J. Biol. Chem. 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:STAT3 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed