JAK2 Phosphorylates STAT5 in Response to Leptin

Stable Identifier
R-HSA-2671829
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated JAK2 phosphorylates STAT5 (at phosphotyrosine-694 of STAT5A and probably at the homologous residue in STAT5B) while STAT5 and JAK2 are bound to LEPR (Briscoe et al. 2001).

Literature References
PubMed ID Title Journal Year
11448122 Leptin receptor long-form signalling in a human liver cell line Cytokine 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:STAT5 [plasma membrane]
Physical Entity
Activity
Inferred From