Phosphorylated LEPR Binds SHP2 (PTPN11)

Stable Identifier
R-HSA-2671747
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

SHP2 (PTPN11) interacts with phosphotyrosine-986 of the phosphorylated Leptin receptor (LEPR) (Carpenter et al. 1998). The corresponding site in mouse is phosphotyrosine-985 and in rat phosphotyrosine-986.
SHP2 and SOCS3 compete for the same binding site on LEPR. SHP2 activates MAPK signaling, probably by recruiting GRB2:SOS which activates RAS.

Literature References
PubMed ID Title Journal Year
9600917 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Carpenter, LR, Farruggella, TJ, Symes, A, Karow, ML, Yancopoulos, GD, Stahl, N

Proc. Natl. Acad. Sci. U.S.A. 1998
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