JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin

Stable Identifier
R-HSA-2671742
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated JAK2 in the LEP:LEPR:JAK2:SHP2 complex phosphorylates SHP2 (Carpenter et al. 1998). Phosphorylated SHP2, in turn, activates the RAS-MAPK signaling pathway, possibly via GRB2:SOS.

Literature References
PubMed ID Title Journal Year
9600917 Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

Carpenter, LR, Farruggella, TJ, Symes, A, Karow, ML, Yancopoulos, GD, Stahl, N

Proc. Natl. Acad. Sci. U.S.A. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:SHP2 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created