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LTC4S [nuclear envelope]
Stable Identifier
R-HSA-266025
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Leukotriene C4 synthase, LTC4S_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Synthesis of Lipoxins (LX) (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5 oxidises 15S-HpETE to LXA4/B4 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
5S-HpETE is dehydrated to LTA4 by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5 binds ALOX5 inhibitors (Homo sapiens)
ALOX5:ALOX5 inhibitors [nuclear envelope] (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
Arachidonic acid is oxidised to 5S-HpETE by ALOX5 (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
EXA4 is converted to EXC4 by LTC4S (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
LTA4 is converted to LTC4 by LTC4S (Homo sapiens)
ALOX5:ALOX5AP:LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
LTC4S trimer [nuclear envelope] (Homo sapiens)
LTC4S [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16873 LTC4S
Gene Names
LTC4S
Chain
chain:1-150
Reference Genes
BioGPS Gene:4056 LTC4S
COSMIC (genes):LTC4S LTC4S
CTD Gene:4056 LTC4S
dbSNP Gene:4056 LTC4S
ENSEMBL:ENSG00000213316 LTC4S
ENSEMBL_homo_sapiens_GENE:ENSG00000213316.10 LTC4S
ENSEMBL_homo_sapiens_GENE:ENSG00000283887.2 LTC4S
HGNC:6719 LTC4S
KEGG Gene (Homo sapiens):4056 LTC4S
Monarch:4056 LTC4S
NCBI Gene:4056 LTC4S
OMIM:246530 LTC4S
UCSC:Q16873 LTC4S
Reference Transcript
RefSeq:NM_145867.1 LTC4S
Other Identifiers
11729075_s_at
16993451
206480_PM_at
206480_at
2844462
2844463
2844465
2844468
2844470
2844471
2844473
2844474
2844475
2844476
39968_at
4056
8110562
GE80456
GO:0003824
GO:0004364
GO:0004464
GO:0004602
GO:0005515
GO:0005634
GO:0005635
GO:0005640
GO:0005783
GO:0005789
GO:0006629
GO:0006691
GO:0008047
GO:0008289
GO:0016020
GO:0016209
GO:0016491
GO:0016740
GO:0016829
GO:0019370
GO:0031965
GO:0042759
GO:0042802
GO:0043226
GO:0043231
GO:0098754
GO:0098772
GO:0098869
HMNXSV003023196
ILMN_1668247
TC05003417.hg
U50136_rna1_at
g4505040_3p_at
Participates
as a component of
LTC4S trimer [nuclear envelope] (Homo sapiens)
Other forms of this molecule
LTC4S [endoplasmic reticulum membrane]
Inferred To
ltc4s [nuclear envelope]
(Xenopus tropicalis)
ltc4s.2 [nuclear envelope]
(Xenopus tropicalis)
mgst [nuclear envelope]
(Dictyostelium discoideum)
Homologues of LTC4S [nuclear envelope]
(Xenopus tropicalis)
LTC4S [nuclear envelope]
(Bos taurus)
LTC4S [nuclear envelope]
(Canis familiaris)
LTC4S [nuclear envelope]
(Gallus gallus)
LTC4S [nuclear envelope]
(Mus musculus)
LTC4S [nuclear envelope]
(Rattus norvegicus)
LTC4S [nuclear envelope]
(Sus scrofa)
Cross References
RefSeq
NP_665874.1
Guide to Pharmacology - Targets
1391
OpenTargets
ENSG00000213316
GeneCards
Q16873
HPA
ENSG00000213316-LTC4S
ZINC target
Q16873
Ensembl
ENSP00000492334
,
ENSG00000283887
,
ENST00000292596
,
ENSG00000213316
,
ENST00000639087
,
ENSP00000292596
PRO
Q16873
Pharos - Targets
Q16873
HMDB Protein
HMDBP00807
PDB
3B29
,
4J7T
,
6R7D
,
4J7Y
,
4JC7
,
3HKK
,
4JRZ
,
4JCZ
,
4BPM
,
3PCV
,
5HV9
,
4WAB
,
2UUH
,
2PNO
,
3LEO
,
2UUI
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
5
UniProt:O14843 FFAR3
1
FFAR3 [plasma membrane]
(R-HSA-443951)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
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