Reactome | Corticotropin cleavage from POMC

Corticotropin cleavage from POMC

Stable Identifier

R-HSA-265301

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Corticotropin (adrenocorticotropic hormone, ACTH) is a 39-amino acid polypeptide hormone produced and secreted by the pituitary gland. It is often produced in response to biological stress (along with corticotropin-releasing hormone). Its principal effects are increased production of androgens and cortisol. Corticotropin is processed from the precursor pro-opiomelanocortin (POMC). The enzyme that performs the cleavage of POMC to corticotropin is prohormone convertase 1 (PC1). In addition to corticotropin, POMC is processed into other small, biologically active fragments. These include lipotropins, melanocyte-stimulating hormone and endorphins.

Literature References

PubMed ID	Title	Journal	Year
14463577	On the structure of human corticotropin (adrenocorticotropic hormone) Lerner, AB, Buettner-Janusch, V, Lee, TH	J Biol Chem	1961
9207799	Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene Creemers, JW, Sanders, L, Raffin-Sanson, ML, Jackson, RS, Montague, CT, O'Rahilly, S, Hutton, JC, Ohagi, S	Nat Genet	1997